Mesonephric-like adenocarcinoma of the ovary with squamoid morular metaplasia, aberrant β-catenin expression, and concurrent FGFR2 and CTNNB1 mutations: A case report Journal Article
| Authors: | Xu, J.; Park, K. J.; Rehrauer, W. M.; Weisman, P. S. |
| Article Title: | Mesonephric-like adenocarcinoma of the ovary with squamoid morular metaplasia, aberrant β-catenin expression, and concurrent FGFR2 and CTNNB1 mutations: A case report |
| Abstract: | In general, endometrioid-defining features such as squamoid morular metaplasia are not thought to be associated with mesonephric adenocarcinoma (MA) and mesonephric-like adenocarcinoma (MLA). Here, we report a case of FGFR2-mutated ovarian MLA with squamoid morular metaplasia accompanied by aberrant nuclear and cytoplasmic β-catenin expression and CTNNB1 mutation. Histologically, the tumor showed classical MLA histology, including well-formed glands with intraluminal eosinophilic secretions and cells with papillary thyroid carcinoma-like nuclei. Squamoid morular metaplasia was intimately associated with the tumor. Glandular epithelial elements, including those immediately associated with the squamoid morules, were negative for ER, but positive for both GATA3 and PAX8; aberrant β-catenin expression was limited to the squamoid morules. This case illustrates the ability of mesonephric neoplasia to exhibit histological features previously thought to be restricted to an endometrioid phenotype. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
| Keywords: | metaplasia; genetics; mutation; case report; adenocarcinoma; metabolism; pathology; ovary; beta catenin; ctnnb1 protein, human; fibroblast growth factor receptor 2; receptor, fibroblast growth factor, type 2; β-catenin; fgfr2; humans; human; female; fgfr2 protein, human; mesonephric-like adenocarcinoma; squamoid morules |
| Journal Title: | Virchows Archiv |
| Volume: | 484 |
| Issue: | 1 |
| ISSN: | 0945-6317 |
| Publisher: | Springer |
| Date Published: | 2024-01-01 |
| Start Page: | 147 |
| End Page: | 150 |
| Language: | English |
| DOI: | 10.1007/s00428-023-03522-9 |
| PUBMED: | 36856760 |
| PROVIDER: | scopus |
| PMCID: | PMC11826962 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- Source: Scopus |
