Clinicopathologic characteristics of mesonephric adenocarcinomas and mesonephric-like adenocarcinomas in the gynecologic tract: A multi-institutional study Journal Article


Authors: Pors, J.; Segura, S.; Chiu, D. S.; Almadani, N.; Ren, H. Z.; Fix, D. J.; Howitt, B. E.; Kolin, D.; McCluggage, W. G.; Mirkovic, J.; Gilks, B.; Park, K. J.; Hoang, L.
Article Title: Clinicopathologic characteristics of mesonephric adenocarcinomas and mesonephric-like adenocarcinomas in the gynecologic tract: A multi-institutional study
Abstract: Mesonephric adenocarcinoma (MA) and mesonephric-like adenocarcinoma (MLA) are uncommon neoplasms of the gynecologic tract that have until recently been poorly understood. Although their morphologic, immunohistochemical, and molecular profiles have been recently defined, little is known about their clinical behavior. Small studies have demonstrated inconsistent findings and no large studies have examined the clinical behavior of these adenocarcinomas. In this multi-institutional study, representing the largest and most stringently defined cohort of cases to date, we examined the clinicopathologic features of 99 MAs and MLAs (30 MAs of the uterine cervix, 44 MLAs of the endometrium, and 25 MLAs of the ovary). Only tumors with characteristic mesonephric morphology and either immunohistochemical or molecular support were included. Our results demonstrate that the majority of mesonephric neoplasms presented at an advanced stage (II to IV) (15/25 [60%] MA of the cervix, 25/43 [58%] MLA of the endometrium, and 7/18 [39%] MLA of the ovary). The majority (46/89 [52%] overall, 12/24 [50%] MA of the cervix, 24/41 [59%] MLA of the endometrium, and 10/24 [42%] MLA of the ovary) developed recurrences, most commonly distant (9/12 [75%] MA of the cervix, 22/24 [92%] MLA of the endometrium, and 5/9 [56%] MLA of the ovary). The 5-year disease-specific survival was 74% (n=26) for MA of cervix, 72% (n=43) for MLA of endometrium, and 71% (n=23) for MLA of ovary. Our results confirm that mesonephric neoplasms are a clinically aggressive group of gynecologic carcinomas that typically present at an advanced stage, with a predilection for pulmonary recurrence.
Keywords: immunohistochemistry; neoplasms; carcinoma; outcomes; uterine cervix; presentation; clear-cell; marker; endometrial; clinical; lung metastases; prognosis; mesonephric carcinoma; mesonephric-like carcinoma; recurrent kras mutations; napsin
Journal Title: American Journal of Surgical Pathology
Volume: 45
Issue: 4
ISSN: 0147-5185
Publisher: Lippincott Williams & Wilkins  
Date Published: 2021-04-01
Start Page: 498
End Page: 506
Language: English
ACCESSION: WOS:000647761800006
DOI: 10.1097/pas.0000000000001612
PROVIDER: wos
PMCID: PMC7954854
PUBMED: 33165093
Notes: Article -- Source: Wos
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  1. Kay Jung Park
    308 Park
  2. Sheila Elaika Segura
    12 Segura
  3. Daniel Jonas Fix
    10 Fix