Oncology for the rhinologist Review
| Authors: | Tam, K.; Dunn, L. A.; Cohen, M. A. |
| Review Title: | Oncology for the rhinologist |
| Abstract: | Purpose of reviewThe purpose of this review is to summarize current evidence regarding the use of induction chemotherapy for a variety of histopathologies of sinonasal malignancy (SNMs) and to review the potential adverse effects of cytotoxic agents.Recent findingsHistorically, patients with locally advanced SNMs have had relatively poor prognoses and high morbidity from treatment. The available retrospective data suggests that induction chemotherapy may improve outcomes for patients with sinonasal undifferentiated carcinoma (SNUC), neuroendocrine carcinoma, squamous cell carcinoma (SSCC), and esthesioneuroblastoma. For SNUC and SSCC, response or nonresponse to induction chemotherapy may prognosticate outcomes and for SNUC specifically, drive selection of definitive therapy. In chemosensitive pathologies, induction chemotherapy appears to improve organ preservation.SummaryInduction chemotherapy may improve functional and oncologic outcomes for patients with SNMs. Because of the rarity of these pathologies, the available data is primarily retrospective. Future randomized, prospective studies should be performed to further optimize and elucidate the role of induction chemotherapy for SNMs. © 2024 Lippincott Williams and Wilkins. All rights reserved. |
| Keywords: | treatment response; retrospective studies; histopathology; neutropenia; review; squamous cell carcinoma; carcinoma, squamous cell; cisplatin; fluorouracil; advanced cancer; diarrhea; paclitaxel; outcome assessment; prospective study; prospective studies; anorexia; carboplatin; infection; anemia; etoposide; kidney disease; leukopenia; nausea; stomatitis; thrombocytopenia; vomiting; morbidity; pathology; oncology; retrospective study; cetuximab; ifosfamide; docetaxel; febrile neutropenia; lung embolism; heart infarction; organ preservation; alopecia; esthesioneuroblastoma; adverse drug reaction; hearing impairment; chemoradiotherapy; induction chemotherapy; neuroendocrine carcinoma; carcinoma, neuroendocrine; nose cancer; randomized controlled trial (topic); meta analysis (topic); kidney dysfunction; multicenter study (topic); otorhinolaryngology; maxillary sinus neoplasms; sinonasal undifferentiated carcinoma; cancer prognosis; humans; human; sinonasal malignancies; sinonasal squamous cell carcinoma; maxillary sinus tumor |
| Journal Title: | Current Opinion in Otolaryngology & Head and Neck Surgery |
| Volume: | 32 |
| Issue: | 1 |
| ISSN: | 1068-9508 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2024-02-01 |
| Start Page: | 14 |
| End Page: | 19 |
| Language: | English |
| DOI: | 10.1097/moo.0000000000000951 |
| PUBMED: | 38116847 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Marc A. Cohen -- Source: Scopus |
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