Sinonasal carcinomas Book Section
| Author: | Dogan, S. |
| Editors: | Tafe, L. J.; Arcila, M. E. |
| Article/Chapter Title: | Sinonasal carcinomas |
| Abstract: | Sinonasal carcinomas (SNC) comprise a diverse morphologic and genetic spectrum of tumors. NUT carcinoma, SMARCB1-deficient SNC, and sinonasal undifferentiated carcinoma (SNUC) are rare and biologically aggressive, and, although often histologically remarkably similar, these three entities are genetically very distinct. An accurate molecular diagnosis portends a diagnostic value and can identify patients eligible for clinical trials with targeted therapies. Immunohistochemistry (IHC) for NUT and SMARCB1 (INI1) are useful surrogate diagnostic markers in all NUT and SMARCB1-deficient SNC, respectively. IDH2 R172S/T (11C8B1) IHC is a useful adjunct diagnostic marker in at least 70% SNUC. © Springer Nature Switzerland AG 2020. |
| Keywords: | immunohistochemistry; clinical trial; diagnostic value; sinonasal; molecular diagnosis; undifferentiated carcinomas; spectra's; diagnostic markers; morpho-logics |
| Book Title: | Genomic Medicine: A Practical Guide |
| ISBN: | 978-3-030-22921-4 |
| Publisher: | Springer |
| Publication Place: | Cham, Switzerland |
| Date Published: | 2020-01-01 |
| Start Page: | 197 |
| End Page: | 203 |
| Language: | English |
| DOI: | 10.1007/978-3-030-22922-1_13 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book chapter: 13 -- Source: Scopus |
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