A road map for the treatment of pediatric diffuse midline glioma Editorial
| Authors: | Koschmann, C.; Al-Holou, W. N.; Alonso, M. M.; Anastas, J.; Bandopadhayay, P.; Barron, T.; Becher, O.; Cartaxo, R.; Castro, M. G.; Chung, C.; Clausen, M.; Dang, D.; Doherty, R.; Duchatel, R.; Dun, M.; Filbin, M.; Franson, A.; Galban, S.; Garcia Moure, M.; Garton, H.; Gowda, P.; Marques, J. G.; Hawkins, C.; Heath, A.; Hulleman, E.; Ji, S.; Jones, C.; Kilburn, L.; Kline, C.; Koldobskiy, M. A.; Lim, D.; Lowenstein, P. R.; Lu, Q. R.; Lum, J.; Mack, S.; Magge, S.; Marini, B.; Martin, D.; Marupudi, N.; Messinger, D.; Mody, R.; Morgan, M.; Mota, M.; Muraszko, K.; Mueller, S.; Natarajan, S. K.; Nazarian, J.; Niculcea, M.; Nuechterlein, N.; Okada, H.; Opipari, V.; Pai, M. P.; Pal, S.; Peterson, E.; Phoenix, T.; Prensner, J. R.; Pun, M.; Raju, G. P.; Reitman, Z. J.; Resnick, A.; Rogawski, D.; Saratsis, A.; Sbergio, S. G.; Souweidane, M.; Stafford, J. M.; Tzaridis, T.; Venkataraman, S.; Vittorio, O.; Wadden, J.; Wahl, D.; Wechsler-Reya, R. J.; Yadav, V. N.; Zhang, X.; Zhang, Q.; Venneti, S. |
| Title: | A road map for the treatment of pediatric diffuse midline glioma |
| Abstract: | Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much promise. We present a consensus roadmap and identify three major barriers: (1) refinement of experimental models to include immune and brain-specific components; (2) collaboration among researchers, clinicians, and industry to integrate patient-derived data through sharing, transparency, and regulatory considerations; and (3) streamlining clinical efforts including biopsy, CNS-drug delivery, endpoint determination, and response monitoring. We highlight the importance of comprehensive collaboration to advance the understanding, diagnostics, and therapeutics for DMGs. © 2023 Elsevier Inc. |
| Keywords: | glioma; consensus; central nervous system; diagnosis; bioassay; drug therapy; therapy; drug delivery system; human; article |
| Journal Title: | Cancer Cell |
| Volume: | 42 |
| Issue: | 1 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2024-01-08 |
| Language: | English |
| DOI: | 10.1016/j.ccell.2023.11.002 |
| PUBMED: | 38039965 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Note -- Source: Scopus |
