A nonneural miRNA cluster mediates hearing via repression of two neural targets Journal Article
| Authors: | Zhang, B.; Duan, H.; Kavaler, J.; Wei, L.; Eberl, D. F.; Lai, E. C. |
| Article Title: | A nonneural miRNA cluster mediates hearing via repression of two neural targets |
| Abstract: | We show here that mir-279/996 are absolutely essential for development and function of Johnston’s organ (JO), the primary proprioceptive and auditory organ in Drosophila. Their deletion results in highly aberrant cell fate determination, including loss of scolopale cells and ectopic neurons, and mutants are electrophysiologically deaf. In vivo activity sensors and mosaic analyses indicate that these seed-related miRNAs function autonomously to suppress neural fate in nonneuronal cells. Finally, genetic interactions pinpoint two neural targets (elav and insensible) that underlie miRNA mutant JO phenotypes. This work uncovers how critical post-transcriptional regulation of specific miRNA targets governs cell specification and function of the auditory system. © 2023 Zhang et al. This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
| Keywords: | genetics; animal; animals; microrna; drosophila; physiology; hearing; micrornas; drosophila proteins; drosophila protein; sense organ; sense organs; johnston’s organ; neuron] |
| Journal Title: | Genes and Development |
| Volume: | 37 |
| Issue: | 21-24 |
| ISSN: | 0890-9369 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2023-11-01 |
| Start Page: | 1041 |
| End Page: | 1051 |
| Language: | English |
| DOI: | 10.1101/gad.351052.123 |
| PUBMED: | 38110249 |
| PROVIDER: | scopus |
| PMCID: | PMC10760640 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF. Corresponding MSK author is Eric C. Lai -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work