Methods for the production of radiolabeled bioagents for ImmunoPET Journal Article
| Authors: | Arroyo, A.; Lyashchenko, S. K.; Lewis, J. S. |
| Article Title: | Methods for the production of radiolabeled bioagents for ImmunoPET |
| Abstract: | Immunoglobulin-based positron emission tomography (ImmunoPET) is making increasingly significant contributions to the nuclear imaging toolbox. The exquisite specificity of antibodies combined with the high-resolution imaging of PET enables clinicians and researchers to localize diseases, especially cancer, with a high degree of spatial certainty. This review focuses on the radiopharmaceutical preparation necessary to obtain those images—the work behind the scenes, which occurs even before the patient or animal is injected with the radioimmunoconjugate. The focus of this methods review will be the chelation of four radioisotopes to their most common and clinically relevant chelators. © The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2024. |
| Keywords: | positron emission tomography; radiopharmaceuticals; neoplasm; neoplasms; animal; animals; positron-emission tomography; radiopharmaceutical agent; antibodies; radioisotope; radioisotopes; antibody; zirconium; chelating agents; immunopet; radioimmunoconjugate; chelating agent; procedures; humans; human; chelator; <sup>124</sup>i; <sup>64</sup>cu; <sup>86</sup>y; <sup>89</sup>zr; antibody radiolabeling |
| Journal Title: | Methods in Molecular Biology |
| Volume: | 2729 |
| ISSN: | 1064-3745 |
| Publisher: | Humana Press Inc |
| Date Published: | 2024-01-01 |
| Start Page: | 117 |
| End Page: | 142 |
| Language: | English |
| DOI: | 10.1007/978-1-0716-3499-8_8 |
| PROVIDER: | scopus |
| PUBMED: | 38006494 |
| PMCID: | PMC11330323 |
| DOI/URL: | |
| Notes: | Chapter 8 in "Positron Emission Tomography: Methods and Protocols" (ISBN: 978-1-0716-3498-1) -- Source: Scopus |
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