(89)Zr-labeled paramagnetic octreotide-liposomes for PET-MR imaging of cancer Journal Article
| Authors: | Abou, D. S.; Thorek, D. L. J.; Ramos, N. N.; Pinkse, M. W. H.; Wolterbeek, H. T.; Carlin, S. D.; Beattie, B. J.; Lewis, J. S. |
| Article Title: | (89)Zr-labeled paramagnetic octreotide-liposomes for PET-MR imaging of cancer |
| Abstract: | Purpose: Dual-modality PET/MR platforms add a new dimension to patient diagnosis with high resolution, functional, and anatomical imaging. The full potential of this emerging hybrid modality could be realized by using a corresponding dual-modality probe. Here, we report pegylated liposome (LP) formulations, housing a MR T1 contrast agent (Gd) and the positron-emitting 89Zr (half-life: 3.27 days), for simultaneous PET and MR tumor imaging capabilities. Methods: 89Zr oxophilicity was unexpectedly found advantageous for direct radiolabeling of preformed paramagnetic LPs. LPs were conjugated with octreotide to selectively target neuroendocrine tumors via human somatostatin receptor subtype 2 (SSTr2). 89Zr-Gd-LPs and octreotide-conjugated homolog were physically, chemically and biologically characterized. Results: 89Zr-LPs showed reasonable stability over serum proteins and chelator challenges for proof-of-concept in vitro and in vivo investigations. Nuclear and paramagnetic tracking quantified superior SSTr2-recognition of octreotide-LP compared to controls. Conclusions: This study demonstrated SSTr2-targeting specificity along with direct chelator-free 89Zr-labeling of LPs and dual PET/MR imaging properties. © 2012 Springer Science+Business Media New York. |
| Keywords: | nanoparticles; octreotide; 89zr; pet-mri; targeted molecular imaging |
| Journal Title: | Pharmaceutical Research |
| Volume: | 30 |
| Issue: | 3 |
| ISSN: | 0724-8741 |
| Publisher: | Springer Science + Business Media, LLC |
| Date Published: | 2013-03-01 |
| Start Page: | 878 |
| End Page: | 888 |
| Language: | English |
| DOI: | 10.1007/s11095-012-0929-8 |
| PROVIDER: | scopus |
| PMCID: | PMC3578092 |
| PUBMED: | 23224977 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 July 2013" - "CODEN: PHREE" - "Source: Scopus" |
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