Few and far between: Clinical management of rare extranodal subtypes of mature T-cell and NK-cell lymphomas Review
| Authors: | Stuver, R.; Epstein-Peterson, Z. D.; Horwitz, S. M. |
| Review Title: | Few and far between: Clinical management of rare extranodal subtypes of mature T-cell and NK-cell lymphomas |
| Abstract: | While all peripheral T-cell lymphomas are uncommon, certain subtypes are truly rare, with less than a few hundred cases per year in the USA. There are often no dedicated clinical trials in these rare subtypes, and data are generally limited to case reports and retrospective case series. Therefore, clinical management is often based on this limited literature and extrapolation of data from the more common, nodal T-cell lymphomas in conjunction with personal experience. Nevertheless, thanks to tremendous pre-clinical efforts to understand these rare diseases, an increasing appreciation of the biological changes that underlie these entities is forming. In this review, we attempt to summarize the relevant literature regarding the initial management of certain rare subtypes, specifically subcutaneous panniculitis-like T-cell lymphoma, hepatosplenic T-cell lymphoma, intestinal T-cell lymphomas, and extranodal NK/T-cell lymphoma. While unequivocally established approaches in these diseases do not exist, we make cautious efforts to provide our approaches to clinical management when possible. © 2023 Ferrata Storti Foundation. |
| Keywords: | immunohistochemistry; human tissue; retrospective studies; lenalidomide; review; doxorubicin; radiation dose; cytarabine; methotrexate; positron emission tomography; follow up; cell proliferation; t lymphocyte; t-lymphocytes; interleukin 2; progression free survival; bortezomib; computer assisted tomography; multiple myeloma; etoposide; cytogenetics; cyclophosphamide; melphalan; vincristine; cell differentiation; pathology; chemosensitivity; retrospective study; risk factor; histology; ifosfamide; peripheral t cell lymphoma; t cell lymphoma; bone marrow biopsy; panniculitis; asparaginase; natural killer cell; killer cells, natural; platinum; immunophenotyping; triacylglycerol; lymphocytic infiltration; cd5 antigen; romidepsin; cyclosporine; ferritin; fibrinogen; nk t cell lymphoma; hemophagocytic syndrome; programmed death 1 ligand 1; lymphoma, t-cell, peripheral; hepatosplenic t cell lymphoma; bexarotene; infliximab; inflammatory bowel disease; lupus erythematosus; humans; human; female; pembrolizumab; avelumab; subcutaneous t cell lymphoma; extranodal natural killer/t-cell lymphoma; sintilimab; lymphoma, extranodal nk-t-cell; sugemalimab |
| Journal Title: | Haematologica |
| Volume: | 108 |
| Issue: | 12 |
| ISSN: | 0390-6078 |
| Publisher: | Ferrata Storti Foundation |
| Date Published: | 2023-12-01 |
| Start Page: | 3244 |
| End Page: | 3260 |
| Language: | English |
| DOI: | 10.3324/haematol.2023.282717 |
| PUBMED: | 38037801 |
| PROVIDER: | scopus |
| PMCID: | PMC10690914 |
| DOI/URL: | |
| Notes: | Review -- MSK corresponding author is Robert Stuver -- Source: Scopus |
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