Systematic review of challenging issues in pathology of intraductal papillary mucinous neoplasms Review
| Authors: | Wood, L. D.; Adsay, N. V.; Basturk, O.; Brosens, L. A. A.; Fukushima, N.; Hong, S. M.; Kim, S. J.; Lee, J. W.; Luchini, C.; Noë, M.; Pitman, M. B.; Scarpa, A.; Singhi, A. D.; Tanaka, M.; Furukawa, T. |
| Review Title: | Systematic review of challenging issues in pathology of intraductal papillary mucinous neoplasms |
| Abstract: | Background: Intraductal papillary mucinous neoplasms (IPMNs) are a cystic precursor to pancreatic cancer. IPMNs deemed clinically to be at high-risk for malignant progression are frequently treated with surgical resection, and pathological examination of the pancreatectomy specimen is a key component of the clinical care of IPMN patients. Methods: Systematic literature reviews were conducted around eight topics of clinical relevance in the examination of pathological specimens in patients undergoing resection of IPMN. Results: This review provides updated perspectives on morphological subtyping of IPMNs, classification of intraductal oncocytic papillary neoplasms, nomenclature for high-grade dysplasia, assessment of T stage, distinction of carcinoma associated or concomitant with IPMN, role of molecular assessment of IPMN tissue, role of intraoperative assessment by frozen section, and preoperative evaluation of cyst fluid cytology. Conclusions: This analysis provides the foundation for data-driven approaches to several challenging issues in the pathology of IPMNs. © 2023 |
| Keywords: | adult; excision; retrospective studies; missense mutation; pancreas cancer; pancreatic neoplasms; preoperative evaluation; intraductal papillary mucinous tumor; adenocarcinoma, mucinous; carcinoma, pancreatic ductal; pathology; retrospective study; systematic review; pancreas tumor; epithelium cell; pancreatectomy; invasive carcinoma; nomenclature; heterozygosity loss; high risk population; frozen section; colloid carcinoma; dysplasia; interrater reliability; pancreatic ductal carcinoma; dna sequencing; humans; human; female; article; pancreatic intraductal neoplasms; pancreatic intraductal neoplasia |
| Journal Title: | Pancreatology |
| Volume: | 23 |
| Issue: | 7 |
| ISSN: | 1424-3903 |
| Publisher: | Karger |
| Date Published: | 2023-01-01 |
| Start Page: | 878 |
| End Page: | 891 |
| Language: | English |
| DOI: | 10.1016/j.pan.2023.08.002 |
| PUBMED: | 37604731 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
