Intraductal papillary mucinous neoplasms of the pancreas: Clinical and pathological features and diagnostic approach Journal Article
| Authors: | Katabi, N.; Klimstra, D. S. |
| Article Title: | Intraductal papillary mucinous neoplasms of the pancreas: Clinical and pathological features and diagnostic approach |
| Abstract: | Pancreatic intraductal papillary mucinous neoplasms (IPMNs) are mucin-producing neoplasms with a frequent papillary architecture that arise within the pancreatic ducts and are increasingly being recognised. Because they exhibit a spectrum of dysplasia ranging from low grade to high grade and may also have associated invasive carcinoma, and because they are clinically detectable, they are now intensively studied. There is marked overlap between IPMNs and pancreatic intraepithelial neoplasia (PanIN), such that the distinction between these two lesions is nearly impossible in certain cases. In addition, IPMNs sometimes can be confused with other primary cystic lesions of the pancreas. As a result, the correct diagnosis of IPMN can be challenging. This review addresses the clinical and pathological features of IPMNs, emphasising their diagnostic criteria, differential diagnosis and biological behaviour. Problematic issues in the pathological evaluation of IPMNs are discussed. |
| Keywords: | immunohistochemistry; cancer surgery; clinical feature; review; pancreatic neoplasms; diagnostic accuracy; diagnostic procedure; diagnosis, differential; differential diagnosis; intraductal papillary mucinous tumor; pancreas cyst; adenocarcinoma, mucinous; carcinoma, pancreatic ductal; tumor markers, biological; histology; carcinoma in situ; pancreas duct; pancreas tumor; pancreatectomy; invasive carcinoma; neoplasm invasiveness; dysplasia; pancreatic intraepithelial neoplasia; intraductal oncocytic papillary neoplasm; intraductal tubular carcinoma; intraductal tubular neoplasm |
| Journal Title: | Journal of Clinical Pathology |
| Volume: | 61 |
| Issue: | 12 |
| ISSN: | 0021-9746 |
| Publisher: | BMJ Publishing Group Ltd. |
| Date Published: | 2008-12-01 |
| Start Page: | 1303 |
| End Page: | 1313 |
| Language: | English |
| DOI: | 10.1136/jcp.2007.049361 |
| PUBMED: | 18703569 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 14" - "Export Date: 17 November 2011" - "CODEN: JCPAA" - "Source: Scopus" |
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