A novel SPECT/MRI bimodal imaging probe: (99m)Tc-DPAPA-Fe(3)O(4) nanoconjugate Journal Article
| Authors: | Yasakçı, V.; Tutun, E.; Karatay, K. B.; Aras, Ö; Ünak, P. |
| Article Title: | A novel SPECT/MRI bimodal imaging probe: (99m)Tc-DPAPA-Fe(3)O(4) nanoconjugate |
| Abstract: | This study aimed to create a novel bimodal probe. For this purpose, cubic iron oxide nanoparticles (C-Fe3O4 NPs) conjugated with an EDTMP derivative called DPAPA thought to be a targeting tool for prostate cancer and bone metastases were studied. NPs were synthesized and conjugated with DPAPA, and then characterization studies were carried out. The particles were demonstrated to be cubic shaped, with an average size of 68.55 ± 1 0.03 (n = 3) nm. Then the nanoconjugates were radiolabeled with 99mTc. In vitro cellular affinities were conducted using PC-3, RWPE-1, LNCaP, K562, and Saos-2 cell lines. In conclusion, radio-nanoconjugates have the potential for bimodal MRI/SPECT imaging. © 2023, Akadémiai Kiadó, Budapest, Hungary. |
| Keywords: | controlled study; unclassified drug; bone metastasis; nuclear magnetic resonance imaging; technetium 99m; quality control; in vitro study; prostate cancer; silicon dioxide; radioisotope; thin layer chromatography; synthesis; iron oxide nanoparticle; affinity labeling; transmission electron microscopy; single photon emission computed tomography; scanning electron microscopy; ethylenediamine; prostate cancer cells; radiolabeling; human; article; lncap cell line; saos-2 cell line; k-562 cell line; nanoconjugate; hyperbranched polyglycerol; radiochromatography; <sup>99m</sup>tc; (s)-2,5-bis(bis(phosphonomethyl)amino) pentanoic acid; cubic iron oxide nanoparticles; spect/mri probe; 2,5 bis[bis(phosphonomethyl)amino] pentanoic acid cubic iron oxide tc 99m nanoconjugate; energy dispersive x ray spectroscopy; pc-3 [human pancreatic carcinoma] cell line; rwpe-1 cell line |
| Journal Title: | Journal of Radioanalytical and Nuclear Chemistry |
| Volume: | 332 |
| Issue: | 11 |
| ISSN: | 0236-5731 |
| Publisher: | Springer |
| Date Published: | 2023-11-01 |
| Start Page: | 4651 |
| End Page: | 4666 |
| Language: | English |
| DOI: | 10.1007/s10967-023-08875-8 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Source: Scopus |
