Effects of fluorodeoxyglucose magnetic nanoparticles on NCI-H727 and SH-SY5Y cancer cells Journal Article
| Authors: | Unak, P.; Budiyo, R. C.; Horsnzky, A.; Yasakci, V.; Pearce, G.; Russell, S.; Aras, O.; Akin, O.; Wong, J. |
| Article Title: | Effects of fluorodeoxyglucose magnetic nanoparticles on NCI-H727 and SH-SY5Y cancer cells |
| Abstract: | We present a report regarding the cytotoxic effects of iron-based magnetic nanoparticles conjugated with fluorodeoxyglucose (FDG-mNPs) on the viability of NCI-H727 and SH-SY5Y cancer cells. MTT assays were performed to determine cell viability in treated cancer cells grown under standard 2D culture conditions. FDG-mNP concentrations of 0.075 mg/mL, 0.15 mg/mL, and 0.3 mg/mL decreased mean cell viability of NCI-H727 cells to 92.5%, 82.9%, and 75% respectively. FDG-mNPs was also shown to have a detrimental effect on the viability of SY5Y cells: a decrease of 5.7%, 18.6%, and 36.4% was found for SY5Y cells treated with 0.075 mg/mL, 0.15 mg/mL, and 0.3 mg/mL concentrations of FDG-mNPs, respectively. When NCI-H727 and SH-SY5Y cancer cells were grown as 3D spheroids, morphology was visibly changed and the number of viable cells was decerased in spheroids treated with FDG-mNPs compared with untreated spheroids. The results of our study demonstrated that FDG-mNP has toxic effects on NCI-H7272 and SY5Y cancer cells, and we conclude that conjugated FDG-mNPs are promising in the development of clinical applications for the destruction of cancer cells. © 2021 by SPC (Sami Publishing Company),. |
| Keywords: | fluorodeoxyglucose; spheroids; magnetic nanoparticles; sh-sy5y; nci-h727 |
| Journal Title: | Asian Journal of Nanoscience and Materials |
| Volume: | 4 |
| Issue: | 1 |
| ISSN: | 2645-775X |
| Publisher: | SPC (Sami Publishing Company) |
| Date Published: | 2021-01-01 |
| Start Page: | 53 |
| End Page: | 66 |
| Language: | English |
| DOI: | 10.26655/ajnanomat.2021.1.5 |
| PROVIDER: | scopus |
| PMCID: | PMC10792519 |
| PUBMED: | 38234577 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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