Integrating [18F]-fluorodeoxyglucose positron emission tomography with computed tomography with radiation therapy and immunomodulation in precision therapy for solid tumors Editorial
| Authors: | Prendergast, C. M.; Lopci, E.; Seban, R. D.; De Jong, D.; Ammari, S.; Aneja, S.; Lévy, A.; Sajan, A.; Salvatore, M. M.; Cappacione, K. M.; Schwartz, L. H.; Deutsch, E.; Dercle, L. |
| Title: | Integrating [18F]-fluorodeoxyglucose positron emission tomography with computed tomography with radiation therapy and immunomodulation in precision therapy for solid tumors |
| Abstract: | [18F]-FDG positron emission tomography with computed tomography (PET/CT) imaging is widely used to enhance the quality of care in patients diagnosed with cancer. Furthermore, it holds the potential to offer insight into the synergic effect of combining radiation therapy (RT) with immuno-oncological (IO) agents. This is achieved by evaluating treatment responses both at the RT and distant tumor sites, thereby encompassing the phenomenon known as the abscopal effect. In this context, PET/CT can play an important role in establishing timelines for RT/IO administration and monitoring responses, including novel patterns such as hyperprogression, oligoprogression, and pseudoprogression, as well as immune-related adverse events. In this commentary, we explore the incremental value of PET/CT to enhance the combination of RT with IO in precision therapy for solid tumors, by offering supplementary insights to recently released joint guidelines. © 2023 by the authors. |
| Keywords: | treatment response; nonhuman; solid tumor; note; mouse; melanoma; tumor volume; cell differentiation; tumor regression; granzyme b; cytokine; cellular immunity; immune response; immunotherapy; artificial intelligence; fluorodeoxyglucose f 18; brachytherapy; tumor immunity; pet imaging; radiation therapy; immunomodulation; rheumatoid arthritis; cytotoxic t lymphocyte antigen 4; cytokine release; glucose intake; glycolysis; antigen presenting cell; ablation therapy; tumor resistance; pet/ct; tumor metastasis; programmed death 1 receptor; abscopal effect; tumor microenvironment; tumor biomarkers; metabolic tumor volume; human; positron emission tomography-computed tomography; checkpoint inhibitor therapy; tumor hyperprogression |
| Journal Title: | Cancers |
| Volume: | 15 |
| Issue: | 21 |
| ISSN: | 2072-6694 |
| Publisher: | MDPI |
| Date Published: | 2023-11-01 |
| Start Page: | 5179 |
| Language: | English |
| DOI: | 10.3390/cancers15215179 |
| PROVIDER: | scopus |
| PMCID: | PMC10648321 |
| PUBMED: | 37958353 |
| DOI/URL: | |
| Notes: | Note -- Source: Scopus |
