Positron emission tomography/computerized tomography functional imaging of esophageal and colorectal cancer Journal Article


Authors: Larson, S. M.; Schoder, H.; Yeung, H.
Article Title: Positron emission tomography/computerized tomography functional imaging of esophageal and colorectal cancer
Abstract: Positron Emission Tomography/Computerized Emission Tomography (PET/CT) creates fusion images which are a combination of tissue function (PET) and anatomy (CT). PET/CT imaging for esophageal and colorectal cancers improves staging, detection of recurrence, and treatment monitoring. Both tumor types are highly metabolically active in the untreated state, and the glucose analog, 2-[18F]2-fluoro-2-deoxy-D-glcuose, (FDG), is widely useful as a PET imaging tracer for these malignancies. For esophageal and colorectal malignancies, diagnostic imaging sensitivity and specificity are greater than 90%. For esophageal tumors, PET imaging is standard of care for staging of locally advanced tumor. Fifteen to 20% of patients will have otherwise occult metastatic sites detected by PET imaging at initial staging. Progression free survival and survival are correlated with the magnitude of reduction in PET-FDG measured metabolic activity post-treatment. For colorectal cancers, PET-FDG is standard of care to detect recurrence, and to monitor treatment response. The addition of CT to the PET imaging, causes a significant reduction in uncertainty of image interpretation and improves the distinction between benign and malignant causes for FDG-PET positive sites. Copyright © Jones and Bartlett Publishers, Inc.
Keywords: cancer survival; disease course; review; cancer recurrence; cancer staging; positron emission tomography; cancer diagnosis; neoplasm staging; radiopharmaceuticals; colorectal cancer; tumor localization; metastasis; computer assisted tomography; tomography, x-ray computed; patient monitoring; diagnostic imaging; colorectal neoplasms; patient care; diagnostic agent; disease progression; image quality; colorectal tumor; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; positron-emission tomography; radiopharmaceutical agent; scintiscanning; image processing, computer-assisted; image processing; esophagus cancer; esophagus tumor; esophageal neoplasms; computed tomography; radiographic image enhancement; humans; human; priority journal; article; pet/fdg imaging
Journal Title: The Cancer Journal
Volume: 10
Issue: 4
ISSN: 1528-9117
Publisher: Lippincott Williams & Wilkins  
Date Published: 2004-07-01
Start Page: 243
End Page: 250
Language: English
DOI: 10.1097/00130404-200407000-00005
PROVIDER: scopus
PUBMED: 15383205
DOI/URL:
Notes: Cancer J. -- Cited By (since 1996):24 -- Export Date: 16 June 2014 -- CODEN: CAJOC -- Source: Scopus
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  1. Henry W D Yeung
    126 Yeung
  2. Heiko Schoder
    546 Schoder
  3. Steven M Larson
    959 Larson