Positron emission tomography/computerized tomography functional imaging of esophageal and colorectal cancer Journal Article
| Authors: | Larson, S. M.; Schoder, H.; Yeung, H. |
| Article Title: | Positron emission tomography/computerized tomography functional imaging of esophageal and colorectal cancer |
| Abstract: | Positron Emission Tomography/Computerized Emission Tomography (PET/CT) creates fusion images which are a combination of tissue function (PET) and anatomy (CT). PET/CT imaging for esophageal and colorectal cancers improves staging, detection of recurrence, and treatment monitoring. Both tumor types are highly metabolically active in the untreated state, and the glucose analog, 2-[18F]2-fluoro-2-deoxy-D-glcuose, (FDG), is widely useful as a PET imaging tracer for these malignancies. For esophageal and colorectal malignancies, diagnostic imaging sensitivity and specificity are greater than 90%. For esophageal tumors, PET imaging is standard of care for staging of locally advanced tumor. Fifteen to 20% of patients will have otherwise occult metastatic sites detected by PET imaging at initial staging. Progression free survival and survival are correlated with the magnitude of reduction in PET-FDG measured metabolic activity post-treatment. For colorectal cancers, PET-FDG is standard of care to detect recurrence, and to monitor treatment response. The addition of CT to the PET imaging, causes a significant reduction in uncertainty of image interpretation and improves the distinction between benign and malignant causes for FDG-PET positive sites. Copyright © Jones and Bartlett Publishers, Inc. |
| Keywords: | cancer survival; disease course; review; cancer recurrence; cancer staging; positron emission tomography; cancer diagnosis; neoplasm staging; radiopharmaceuticals; colorectal cancer; tumor localization; metastasis; computer assisted tomography; tomography, x-ray computed; patient monitoring; diagnostic imaging; colorectal neoplasms; patient care; diagnostic agent; disease progression; image quality; colorectal tumor; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; positron-emission tomography; radiopharmaceutical agent; scintiscanning; image processing, computer-assisted; image processing; esophagus cancer; esophagus tumor; esophageal neoplasms; computed tomography; radiographic image enhancement; humans; human; priority journal; article; pet/fdg imaging |
| Journal Title: | The Cancer Journal |
| Volume: | 10 |
| Issue: | 4 |
| ISSN: | 1528-9117 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2004-07-01 |
| Start Page: | 243 |
| End Page: | 250 |
| Language: | English |
| DOI: | 10.1097/00130404-200407000-00005 |
| PROVIDER: | scopus |
| PUBMED: | 15383205 |
| DOI/URL: | |
| Notes: | Cancer J. -- Cited By (since 1996):24 -- Export Date: 16 June 2014 -- CODEN: CAJOC -- Source: Scopus |
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