The promise and limitations of neoadjuvant immune-checkpoint blockade in resectable non–small cell lung cancer Editorial
| Authors: | Cooper, A. J.; Yu, H. A. |
| Title: | The promise and limitations of neoadjuvant immune-checkpoint blockade in resectable non–small cell lung cancer |
| Abstract: | The landscape of neoadjuvant immune-checkpoint blockade for resectable non–small cell lung cancer has become an exciting area of clinical and translational exploration. Cascone and colleagues present a platform study of one cycle of novel immunomodulatory agents prior to surgical resection, offering a unique opportunity to perform translational biomarker studies, though many questions remain regarding the ultimate application to a broader patient population. © 2023 American Association for Cancer Research. |
| Keywords: | cancer chemotherapy; cancer survival; protein expression; overall survival; bevacizumab; interferon; adjuvant therapy; neoadjuvant therapy; rituximab; cancer staging; neoplasm staging; cd8+ t lymphocyte; tumor associated leukocyte; biological marker; ipilimumab; cancer immunotherapy; progression free survival; carcinoma, non-small-cell lung; lung neoplasms; cytotoxicity; pathology; lomustine; health care quality; lung tumor; tumor immunity; immunomodulating agent; neoadjuvant chemotherapy; trastuzumab; transitional cell carcinoma; b raf kinase; predictive value; pertuzumab; personalized medicine; mediastinum lymph node; programmed death 1 ligand 1; programmed death 1 receptor; non small cell lung cancer; phase 2 clinical trial (topic); phase 3 clinical trial (topic); phase 1 clinical trial (topic); drug comparison; immune checkpoint inhibitor; high throughput sequencing; nivolumab; ramucirumab; humans; human; article; pembrolizumab; durvalumab; immune checkpoint inhibitors; osimertinib; atezolizumab; immunological antineoplastic agent; antineoplastic agents, immunological; canakinumab |
| Journal Title: | Cancer Discovery |
| Volume: | 13 |
| Issue: | 11 |
| ISSN: | 2159-8274 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2023-11-01 |
| Start Page: | 2306 |
| End Page: | 2309 |
| Language: | English |
| DOI: | 10.1158/2159-8290.Cd-23-0949 |
| PUBMED: | 37909090 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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