Nipple lesions of the breast: An update on morphologic features, immunohistochemical findings and differential diagnosis Review


Authors: Brogi, E.; Scatena, C.
Review Title: Nipple lesions of the breast: An update on morphologic features, immunohistochemical findings and differential diagnosis
Abstract: Because of the unique anatomic structure of the nipple, a few specific breast lesions occur only at this site. Large lactiferous sinuses may be involved by inflammatory conditions such as squamous metaplasia of lactiferous ducts and ductal ectasia or be the site of uncommon superficial epithelial neoplasms such as nipple adenoma or syringomatous tumor of the nipple. Paget disease of the nipple may be secondary to intraepidermal extension of ductal carcinoma in situ in the underlying lactiferous ducts or develop from malignant transformation of Toker cells. Invasive breast cancer may also arise primarily in the nipple. Most of these conditions present as a palpable mass and/or skin changes with or without nipple discharge. Due to the delicate location and often relatively small size of nipple lesions, biopsy specimens are often superficial and fragmented, and the interpretation is challenging. Knowledge of the morphologic and immunophenotypic features of nipple lesions is essential in making the correct diagnosis. Information on the molecular alterations underpinning nipple neoplasms is currently very limited.
Keywords: cytokeratin 7; management; in-situ; expression; squamous-cell carcinoma; malignant-melanoma; complex; pik3ca; nipple-areola; grade adenosquamous carcinoma; florid papillomatosis; low-grade adenosquamous carcinoma; pagetoid bowens-disease; toker cells; clear cells; lactiferous ducts
Journal Title: Advances in Anatomic Pathology
Volume: 30
Issue: 6
ISSN: 1072-4109
Publisher: Lippincott Williams & Wilkins  
Date Published: 2023-11-01
Start Page: 397
End Page: 414
Language: English
ACCESSION: WOS:001083998300007
DOI: 10.1097/pap.0000000000000413
PROVIDER: wos
PUBMED: 37750594
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Source: Wos
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  1. Edi Brogi
    515 Brogi