Neuroimaging and neurocognitive outcomes in older patients with multiple myeloma treated with chemotherapy and autologous stem cell transplantation Journal Article
| Authors: | Correa, D. D.; Vachha, B. A.; Baser, R. E.; Koch, A.; Wong, P.; Gohel, S.; Giralt, S.; Root, J. C. |
| Article Title: | Neuroimaging and neurocognitive outcomes in older patients with multiple myeloma treated with chemotherapy and autologous stem cell transplantation |
| Abstract: | There is a paucity of research on treatment-related neurotoxicity in older adults with multiple myeloma (MM) treated with high-dose chemotherapy (HDC) and autologous SCT (HDC/ASCT), despite the increasing use of this regimen. We examined resting state functional connectivity (RSFC), gray matter (GM) volume, neurocognitive function (NF), and proinflammatory cytokines (PCy) in older patients with MM pre- and post-HDC/ASCT. Eighteen patients underwent MRI, NF tests, and serum PCy measurements prior to HDC/ASCT, and fifteen patients completed a follow up five-months post-HDC/ASCT. There were significant decreases in RSFC post-HDC/ASCT in (1) the central executive network (CEN) involving the left dorsolateral prefrontal cortex and right posterior parietal cortex (p = 0.022) and (2) the CEN involving the right posterior parietal cortex and the salience network involving the right dorsal anterior cingulate cortex (p = 0.029). There were no significant changes in GM or NF, except for improvements in attention (Digit Span Backward, p = 0.03). There were significant increases in several PCy post-HDC/ASCT (p ≤ 0.05). In conclusion, RSFC decreased in frontal, parietal, and cingulate cortices post-HDC/ASCT, NF was relatively stable, and several PCy increased. These findings are congruent with other studies in cancer patients and provide supporting evidence for the vulnerability of frontoparietal regions to chemotherapy’s adverse effects. © 2023 by the authors. |
| Keywords: | adult; cancer chemotherapy; controlled study; aged; fatigue; neuroimaging; neurotoxicity; nuclear magnetic resonance imaging; outcome assessment; interleukin 2; multiple myeloma; interleukin 10; interleukin 13; interleukin 1beta; interleukin 4; autologous stem cell transplantation; cytokine; cytokines; gamma interferon; interleukin 6; cognition; drug dose; verbal memory; attention; functional magnetic resonance imaging; adverse drug reaction; mri; tumor necrosis factor; brain size; trail making test; center for epidemiological studies depression scale; prefrontal cortex; mini mental state examination; functional connectivity; executive function; human; male; female; article; functional assessment of chronic illness therapy fatigue scale; anterior cingulate; neurocognitive; posterior parietal cortex; dorsolateral prefrontal cortex; gray matter volume; resting state functional connectivity; dorsal anterior cingulate cortex; hopkins verbal learning test; salience network; wechsler adult intelligence scale |
| Journal Title: | Cancers |
| Volume: | 15 |
| Issue: | 18 |
| ISSN: | 2072-6694 |
| Publisher: | MDPI |
| Date Published: | 2023-09-02 |
| Start Page: | 4484 |
| Language: | English |
| DOI: | 10.3390/cancers15184484 |
| PROVIDER: | scopus |
| PMCID: | PMC10526394 |
| PUBMED: | 37760454 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Denise D. Correa -- Source: Scopus |
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