Radiation recall pneumonitis from immune checkpoint inhibitors after extra pulmonary radiation Journal Article
| Authors: | Kao, L. E.; Stover, D. |
| Article Title: | Radiation recall pneumonitis from immune checkpoint inhibitors after extra pulmonary radiation |
| Abstract: | Radiation recall is an unpredictable, poorly understood inflammatory reaction within the confines of previously irradiated tissue that occurs following exposure to a systemic agent. In this article, we will focus on a subcategory of radiation recall, called radiation recall pneumonitis (RRP), precipitated by immune checkpoint inhibitors (ICI). Historically, RRP can develop weeks to years after radiation treatment to the lung, most commonly after receiving certain chemotherapeutic agents, but more recently has been recognized in association with immunotherapy agents (ICIs). Up until now, RRP following exposure to ICIs has been described in patients who have received radiation to the lung itself. Here we present three cases of RRP in patients who received radiation to areas adjacent to the lung parenchyma, and developed pulmonary infiltrates in an area adjacent to the radiation field while on ICI therapy. Since ICI induced RRP is treatable and steroid sensitive, early recognition and treatment are important. © 2023 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology. |
| Keywords: | clinical article; aged; prednisone; case report; drug withdrawal; adjuvant therapy; cancer radiotherapy; positron emission tomography; ipilimumab; computer assisted tomography; multiple cycle treatment; pneumonia; rash; lung metastasis; merkel cell carcinoma; fluorodeoxyglucose; lung infiltrate; computed tomographic angiography; adrenal metastasis; clear cell renal cell carcinoma; pneumonitis; lung parenchyma; nivolumab; cancer; human; male; article; avelumab; squamous cell skin carcinoma; cemiplimab; exertional dyspnea; lung consolidation; anti-pd-1/pd-l1; radiation recall pneumonitis |
| Journal Title: | Respirology Case Reports |
| Volume: | 11 |
| Issue: | 10 |
| ISSN: | 2051-3380 |
| Publisher: | John Wiley & Sons Ltd. |
| Date Published: | 2023-10-01 |
| Start Page: | e01223 |
| Language: | English |
| DOI: | 10.1002/rcr2.1223 |
| PROVIDER: | scopus |
| PMCID: | PMC10507574 |
| PUBMED: | 37731586 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding author is Leslie Kao -- Source: Scopus |
