Effect of treatment interruptions on overall survival in patients with triple-negative breast cancer Journal Article
| Authors: | Chow, R.; Hasan, S.; Choi, J. I.; Fox, J.; Chhabra, A. M.; Marshall, D. C.; Bakst, R. L.; Simone, C. B. |
| Article Title: | Effect of treatment interruptions on overall survival in patients with triple-negative breast cancer |
| Abstract: | INTRODUCTION: Currently, there are no data regarding the impact of treatment interruptions during radiotherapy for breast cancer. In this study, we examine the correlation between treatment interruptions during radiotherapy and outcomes in triple-negative breast cancer patients. METHODS: A total of 35 845 patients with triple-negative breast cancer treated between 2010 and 2014 were identified and analyzed from the National Cancer Database. The number of interrupted radiotherapy treatment days was calculated as the difference between the total elapsed days from the start to end of radiation treatment (both initial treatment and boost treatment, when boost was administered) and the total number of expected treatment days, defined as the number of expected treatment days with an addition of 2 weekend days for every multiple of 5 treatment days. Binomial multivariate regression analysis was used to detect correlates of treatment interruptions, and propensity-score matched multivariable Cox proportional hazard models were used to evaluate the association between treatment interruption and overall survival (OS). RESULTS: When modeled as a continuous variable, longer treatment duration was associated with poorer OS (hazard ratio [HR] = 1.023, 95% confidence interval [CI] = 1.015 to 1.031). In reference to 0-1 days of interruption, patients with 2-5 interrupted days (HR = 1.069, 95% CI = 1.002 to 1.140 interrupted days), 6-10 interrupted days (HR = 1.239, 95% CI = 1.140 to 1.348 interrupted days), and 11-15 interrupted days (HR = 1.265, 95% CI = 1.126 to 1.431 interrupted days) experienced increasing likelihood of mortality. CONCLUSION: In the first study of its kind, we report a correlation between treatment interruptions during adjuvant radiotherapy in triple-negative breast cancer and OS. © The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com. |
| Keywords: | retrospective studies; radiotherapy, adjuvant; cancer staging; neoplasm staging; proportional hazards models; retrospective study; time factors; proportional hazards model; partial mastectomy; adjuvant radiotherapy; mastectomy, segmental; triple negative breast cancer; time factor; humans; human; triple negative breast neoplasms |
| Journal Title: | JNCI: Journal of the National Cancer Institute |
| Volume: | 115 |
| Issue: | 9 |
| ISSN: | 0027-8874 |
| Publisher: | Oxford University Press |
| Date Published: | 2023-09-01 |
| Start Page: | 1029 |
| End Page: | 1035 |
| Language: | English |
| DOI: | 10.1093/jnci/djad127 |
| PUBMED: | 37399094 |
| PROVIDER: | scopus |
| PMCID: | PMC10483262 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Charles Simone -- Source: Scopus |
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