KRAS(G12D) inhibition in pancreatic cancer: Fas expression facilitates immune clearance Editorial

  


Authors: Yeh, C.; Park, W.; Yaeger, R.
Title: KRAS(G12D) inhibition in pancreatic cancer: Fas expression facilitates immune clearance
Abstract: In an article in this issue of Developmental Cell and in a second paper in Cancer Cell, Mahadevan et al. demonstrate that KrasG12D suppression remodels the immunosuppressive microenvironment of KrasG12D pancreatic cancers, recruits activated CD8+ cytotoxic T cells, and epigenetically upregulates Fas expression in cancer cells, leading to tumor clearance via Fas/FasL-mediated apoptosis. © 2023 Elsevier Inc.
Keywords: protein expression; unclassified drug; genetics; nonhuman; note; pancreas cancer; pancreatic neoplasms; antineoplastic agent; cd8+ t lymphocyte; apoptosis; fas ligand; pancreas carcinoma; epigenetics; cancer cell; pancreas tumor; cytotoxic t lymphocyte; tumor immunity; upregulation; genes, ras; k ras protein; protein p21; proto-oncogene proteins p21(ras); oncogene ras; kras protein, human; tumor microenvironment; pancreatic carcinoma; disease clearance; humans; human; mrtx 1133
Journal Title: Developmental Cell
Volume: 58
Issue: 17
ISSN: 1534-5807
Publisher: Cell Press  
Date Published: 2023-09-11
Start Page: 1515
End Page: 1516
Language: English
DOI: 10.1016/j.devcel.2023.08.020
PUBMED: 37699334
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85170044561&doi=10.1016%2fj.devcel.2023.08.020&partnerID=40&md5=02a3c3a2a6b6dc13676b6f3abdaf3914
Notes: Note -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Rona Denit Yaeger
    322 Yaeger
  2. Wungki Park
    99 Park
  3. Celine Yeh
    6 Yeh
Related MSK Work