The treatment of aggressive prolactinomas with everolimus Journal Article
| Authors: | Lin, A. L.; Geer, E. B.; Lala, N.; Page-Wilson, G.; Magge, R.; Young, R. J.; Tabar, V. |
| Article Title: | The treatment of aggressive prolactinomas with everolimus |
| Abstract: | Introduction: Aggressive prolactinomas are life-limiting tumors without a standard of care treatment option after the oral alkylator, temozolomide, fails to provide tumor control. Methods: We reviewed an institutional database of pituitary tumors for patients with aggressive prolactinomas who progressed following treatment with a dopamine receptor agonist, radiotherapy and temozolomide. Within this cohort, we identified four patients who were treated with everolimus and we report their response to this therapy. Treatment response was determined by a neuroradiologist, who manually performed volumetric assessment and determined treatment response by Response Assessments in Neuro-Oncology (RANO) criteria. Results: Three of four patients who were treated with everolimus had a biochemical response to therapy and all patients derived a clinically meaningful benefit based upon suppression of tumor growth. While the best overall response as assessed by RANO criteria was stable disease for the four patients, a minor regression in tumor size was appreciated in two of the four patients. Conclusion: Everolimus is an active agent in the treatment of prolactinomas that warrants further investigation. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
| Keywords: | temozolomide; pathology; targeted therapy; everolimus; hypophysis tumor; pituitary neoplasms; dopamine receptor stimulating agent; prolactinoma; humans; human; dopamine agonists; pituitary carcinoma; aggressive pituitary adenoma |
| Journal Title: | Pituitary |
| Volume: | 26 |
| Issue: | 4 |
| ISSN: | 1386-341X |
| Publisher: | Springer |
| Date Published: | 2023-07-01 |
| Start Page: | 474 |
| End Page: | 481 |
| Language: | English |
| DOI: | 10.1007/s11102-023-01340-5 |
| PUBMED: | 37428396 |
| PROVIDER: | scopus |
| PMCID: | PMC10765418 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record and PDF. Corresponding MSK author is Andrew L. Lin -- Source: Scopus |
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