Real-world experience among patients with relapsed/refractory mantle cell lymphoma after Bruton tyrosine kinase inhibitor failure in Europe: The SCHOLAR-2 retrospective chart review study Journal Article
| Authors: | Hess, G.; Dreyling, M.; Oberic, L.; Gine, E.; Zinzani, P. L.; Linton, K.; Vilmar, A.; Jerkeman, M.; Chen, J. M. H.; Ohler, A.; Stilgenbauer, S.; Thieblemont, C.; Lambert, J.; Zilioli, V. R.; Sancho, J. M.; Jiménez-Ubieto, A.; Fischer, L.; Eyre, T. A.; Keeping, S.; Park, J. E.; Wu, J. J.; Siddiqi, R.; Reitan, J.; Wade, S.; Salles, G. |
| Article Title: | Real-world experience among patients with relapsed/refractory mantle cell lymphoma after Bruton tyrosine kinase inhibitor failure in Europe: The SCHOLAR-2 retrospective chart review study |
| Abstract: | Mantle cell lymphoma (MCL) after relapse is associated with poor prognosis. No standard of care exists and available evidence for treatments is limited, particularly in patients who fail Bruton tyrosine kinase inhibitor (BTKi) therapy. This multicentre retrospective chart review study, SCHOLAR-2, addresses this knowledge gap and reports on data collected from 240 patients with relapsed/refractory MCL in Europe who were treated with BTKi-based therapy between July 2012 and July 2018, and had experienced disease progression while on BTKi therapy or discontinued BTKi therapy due to intolerance. The median overall survival (OS) from initiation of first BTKi therapy was 14.6 months (95% confidence interval [CI] 11.6–20.0) in the overall cohort, 5.5 months (95% CI 3.9–8.2) in 91 patients without post-BTKi therapy, and 23.8 months (95% CI 18.9–30.1) in 149 patients who received post-BTKi therapy (excluding chimeric antigen receptor T-cell treatment). In the latter group, patients received a median of one (range, one to seven) line of post-BTKi therapy, with lenalidomide-containing regimens and bendamustine plus rituximab being the most frequently administered; the median OS from initiation of first post-BTKi therapy was 9.7 months (95% CI 6.3–12.7). These results provide a benchmark for survival in patients with R/R MCL receiving salvage therapy after BTKi failure. © 2022 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd. |
| Keywords: | survival; adult; retrospective studies; clinical trial; mantle cell lymphoma; neoplasm recurrence, local; retrospective study; protein tyrosine kinase inhibitor; europe; multicenter study; tumor recurrence; epidemiology; lymphoma, mantle-cell; humans; human; bruton tyrosine kinase inhibitor; real-world evidence; tyrosine protein kinase inhibitors; post-btki |
| Journal Title: | British Journal of Haematology |
| Volume: | 202 |
| Issue: | 4 |
| ISSN: | 0007-1048 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2023-08-01 |
| Start Page: | 749 |
| End Page: | 759 |
| Language: | English |
| DOI: | 10.1111/bjh.18519 |
| PUBMED: | 36257914 |
| PROVIDER: | scopus |
| PMCID: | PMC10812379 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Gilles Salles -- Source: Scopus |
