Staging system performance and clinical outcomes for cutaneous squamous cell carcinoma of the ear: A single-center retrospective study Journal Article
| Authors: | Navarrete-Dechent, C.; Mori, S.; Connolly, K.; Shah, K.; Dusza, S. W.; Rossi, A. M.; Lee, E. H.; Busam, K. J.; Nehal, K. S. |
| Article Title: | Staging system performance and clinical outcomes for cutaneous squamous cell carcinoma of the ear: A single-center retrospective study |
| Abstract: | BACKGROUNDCutaneous squamous cell carcinoma (cSCC) of the ear is associated with poor outcomes. No studies have evaluated current staging system performance in this specific location.OBJECTIVEDescribe clinicopathologic characteristics and outcomes of ear cSCC and evaluate the performance of current staging systems.METHODSRetrospective study including cases diagnosed and treated at a cancer center from January 2000 to December 2014. Demographic, clinical, and pathologic data were collected from clinical records. Biopsy slides were rereviewed and patients were staged according to the American Joint Committee on Cancer (AJCC) seventh, eighth, and Brigham Women's Hospital (BWH) staging.RESULTSOf 125 patients, the mean age at diagnosis was 71.9 years (SD 12.5), with most men (89.6%, n = 112). Median follow-up was 22.3 months. Local recurrence and survival risk factors were similar to cSCC outside the ear. The Akaike's Information Criterion (AIC) estimates showed that the BWH system better predicted outcomes than the AJCC seventh, and the AJCC eighth, with AIC values of 189.9, 270.5, and 274.1, respectively. Limitations of the study include retrospective design, single center study, and no control group.CONCLUSIONCurrent staging systems perform well at stratifying risk in ear cSCC. © 2023 Lippincott Williams and Wilkins. All rights reserved. |
| Keywords: | cancer survival; controlled study; aged; surgical technique; retrospective studies; major clinical study; overall survival; cancer recurrence; squamous cell carcinoma; carcinoma, squamous cell; cancer staging; outcome assessment; follow up; lymph node dissection; neoplasm staging; sentinel lymph node biopsy; skin neoplasms; risk factors; pathology; retrospective study; risk factor; cancer center; skin tumor; tumor recurrence; lymph node; inner ear; disease specific survival; perineural invasion; mohs micrographic surgery; ear neoplasms; wide excision; clinical outcome; local excision; immune status; ear cancer; ear tumor; hospital planning; humans; prognosis; human; male; female; article; squamous cell skin carcinoma |
| Journal Title: | Dermatologic Surgery |
| Volume: | 49 |
| Issue: | 8 |
| ISSN: | 1076-0512 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2023-08-01 |
| Start Page: | 747 |
| End Page: | 754 |
| Language: | English |
| DOI: | 10.1097/dss.0000000000003842 |
| PUBMED: | 37235869 |
| PROVIDER: | scopus |
| PMCID: | PMC10524321 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Kishwer S. Nehal -- Source: Scopus |
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