Gradient-based volumetric PET parameters on immediate pre-ablation FDG-PET predict local tumor progression in patients with colorectal liver metastasis treated by microwave ablation Journal Article

  

Authors:	Zirakchian Zadeh, M.; Yeh, R.; Kirov, A. S.; Kunin, H. S.; Gönen, M.; Sotirchos, V. S.; Soares, K. S.; Sofocleous, C. T.
Article Title:	Gradient-based volumetric PET parameters on immediate pre-ablation FDG-PET predict local tumor progression in patients with colorectal liver metastasis treated by microwave ablation
Abstract:	Purpose: This study aimed to evaluate the optimal method of segmentation of colorectal liver metastasis (CLM) on immediate pre-ablation PET scans and assess the prognostic value of quantitative pre-ablation PET parameters with regards to local tumor control. A secondary objective was to correlate the target tumor size estimation by PET methods with the tumor measurements on anatomical imaging. Methodology: A prospectively accrued cohort of 55 CLMs (46 patients) treated with real-time 18F-FDG-PET/CT-guided percutaneous microwave ablation was followed-up for a median of 10.8 months (interquartile: 5.5–20.2). Total lesion glycolysis (TLG) and metabolic tumor volume (MTV) values of each CLM were derived from pre-ablation 18F-FDG-PET with gradient and threshold PET segmentation methodologies. The event was defined as local tumor progression (LTP). Time-dependent receiver operating characteristic (ROC) curve analyses were used to assess area under the curves (AUCs). Intraclass correlation (ICC) and 95.0% confidence interval (CI) were performed to measure the linear relationships between the continuous variables. Results: AUCs for prediction of LTP obtained from time-dependent ROC analysis for the gradient technique were higher in comparison to the threshold methodologies (AUCs for TLG and volume were: 0.790 and 0.807, respectively). ICC between PET gradient-based and anatomical measurements were higher in comparison to threshold methodologies (ICC for the longest diameter: 733 (95.0% CI 0.538–0.846), ICC for the shortest diameter:.747 (95.0% CI 0.546–0.859), p-values < 0.001). Conclusions: The gradient-based technique had a higher AUC for prediction of LTP after microwave ablation of CLM and showed the highest correlation with anatomical imaging tumor measurements. © 2023, Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE).
Keywords:	retrospective studies; liver neoplasms; positron emission tomography; radiopharmaceuticals; pathology; diagnostic imaging; retrospective study; colorectal neoplasms; tumor burden; colorectal tumor; liver tumor; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; positron-emission tomography; radiopharmaceutical agent; drug therapy; microwave radiation; microwaves; tumor ablation; local tumor progression; colorectal liver metastasis; humans; prognosis; human; pet segmentation; positron emission tomography-computed tomography; positron emission tomography computed tomography; <sup>18</sup>f-fdg-pet; pet parameters; pet/ct guided ablation
Journal Title:	CardioVascular and Interventional Radiology
Volume:	46
Issue:	7
ISSN:	0174-1551
Publisher:	Springer
Date Published:	2023-07-01
Start Page:	911
End Page:	920
Language:	English
DOI:	10.1007/s00270-023-03470-6
PUBMED:	37268735
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85160844648&doi=10.1007%2fs00270-023-03470-6&partnerID=40&md5=640ef32fc76b96fce7078e95dc9348ad
Notes:	The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF. Corresponding author is MSK author Constantinos T. Sofocleous -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/208240