Clinical outcomes among patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) who received treatment with a covalent BTK and BCL2 inhibitor in the United States: A real-world database study Journal Article
| Authors: | Eyre, T. A.; Hess, L. M.; Sugihara, T.; He, D.; Khanal, M.; Pagel, J. M.; Walgren, R. A.; Abada, P. B.; Konig, H.; Roeker, L. E.; Mato, A. |
| Article Title: | Clinical outcomes among patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) who received treatment with a covalent BTK and BCL2 inhibitor in the United States: A real-world database study |
| Abstract: | This retrospective study using the nationwide de-identified Flatiron Health electronic health record-derived database was designed to evaluate clinical outcomes among patients with chronic lymphocytic leukemia (CLL) who previously received both a covalent Bruton’s tyrosine kinase inhibitor (cBTKi) and B-cell lymphoma 2 inhibitor (BCL2i) in a real-world setting. Outcomes for the immediate next line of therapy following the latter of the cBTKi or BCL2i treatment included: real-world response rate of 34.4% (using methods most consistent with clinical trials); median duration of real-world response of 13.3 months; and median real-world progression-free survival of 9.2 months. Median overall survival was 25.5 months from the start of the immediate next line of therapy. There remains a need for more effective therapies after cBTKi and BCL2i therapy for patients with CLL. © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. |
| Keywords: | chronic lymphocytic leukemia; venetoclax; real-world data; covalent btk inhibitor |
| Journal Title: | Leukemia and Lymphoma |
| Volume: | 64 |
| Issue: | 5 |
| ISSN: | 1042-8194 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2023-01-01 |
| Start Page: | 1005 |
| End Page: | 1016 |
| Language: | English |
| DOI: | 10.1080/10428194.2023.2190436 |
| PUBMED: | 36987650 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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