Dietary and microbiome evidence in multiple myeloma and other plasma cell disorders Review
| Authors: | Shah, U. A.; Parikh, R.; Castro, F.; Bellone, M.; Lesokhin, A. M. |
| Review Title: | Dietary and microbiome evidence in multiple myeloma and other plasma cell disorders |
| Abstract: | Multiple Myeloma (MM) remains an incurable plasma cell neoplasm. Although little is known about the etiology of MM, several metabolic risk factors such as obesity, diabetes mellitus, diet, and the human intestinal microbiome have been linked to the pathogenesis of MM. In this article, we provide a detailed review of dietary and microbiome factors involved in the pathogenesis of MM and their impact on outcomes. Concurrent with treatment advancements that have improved survival in MM, focused efforts are needed to reduce the burden of MM as well as improve MM specific and overall outcomes once MM is diagnosed. The findings presented in this review will provide a comprehensive guide on the evidence available to date of the impact of dietary and other lifestyle interventions on the gut microbiome and on MM incidence, outcomes, and quality of life. Data generated from such studies can help formulate evidence-based guidelines for healthcare providers to counsel individuals at risk such as those with Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smoldering Multiple Myeloma (SMM) as well as MM survivors with respect to their dietary habits. © 2023, The Author(s), under exclusive licence to Springer Nature Limited. |
| Keywords: | review; nonhuman; outcome assessment; quality of life; multiple myeloma; incidence; evidence based practice; stem cell transplantation; risk factor; patient care; plasma cell; diet; minimal residual disease; vitamin d; smoking habit; omega 3 fatty acid; probiotic agent; ascorbic acid; retinol; intestine flora; alcohol consumption; disease exacerbation; hematologic disease; plasma cells; curcumin; whole grain; milk; egg; microflora; paraproteinemia; paraproteinemias; vegetable consumption; microbiota; microbiome; smoldering multiple myeloma; humans; human; fiber intake; monoclonal gammopathy of undetermined significance; fruit consumption; knowledge gap; meat consumption; diet composition; fish consumption |
| Journal Title: | Leukemia |
| Volume: | 37 |
| Issue: | 5 |
| ISSN: | 0887-6924 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2023-05-01 |
| Start Page: | 964 |
| End Page: | 980 |
| Language: | English |
| DOI: | 10.1038/s41375-023-01874-4 |
| PUBMED: | 36997677 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF and PubMed -- MSK corresponding author is Urvi Shah -- Source: Scopus |
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