EASIX score predicts inferior survival after allogeneic hematopoietic cell transplantation Journal Article
| Authors: | Sanchez-Escamilla, M.; Flynn, J.; Devlin, S.; Maloy, M.; Fatmi, S. A.; Tomas, A. A.; Escribano-Serrat, S.; Ponce, D.; Sauter, C. S.; Giralt, S. A.; Scordo, M.; Perales, M. A. |
| Article Title: | EASIX score predicts inferior survival after allogeneic hematopoietic cell transplantation |
| Abstract: | The Endothelial Activation and Stress Index (EASIX) is a prognostic tool that uses common clinical laboratory values and has been shown to predict non-relapse mortality (NRM) and overall survival (OS) at the onset of acute graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT). We hypothesized that EASIX calculated at different time points pre- and post- HCT may predict NRM and OS, and that EASIX calculated at onset of GVHD may predict response to steroids. We evaluated the EASIX score pre- and post-HCT in 152 patients with lymphoid malignancies undergoing unmodified reduced intensity conditioning (RIC) alloHCT with uniform GVHD prophylaxis. In multivariate analysis, EASIX calculated pre-HCT was significantly associated with higher NRM (HR = 1.64, p = 0.009) and lower OS (HR = 1.33, p = 0.046). Furthermore, EASIX calculated at day 30 and at day 100 was associated with increased NRM (HR = 1.65, p < 0.001; and HR = 1.65, p < 0.001) and decreased OS (HR = 1.27, p = 0.018; and HR = 1.49, p < 0.001), independent of HCT-CI, disease and conditioning regimen. Our study shows that high EASIX scores at various time points pre- and post-HCT are significantly associated with poorer overall outcomes. EASIX provides an independent and easily accessible tool to predict outcomes that can be complementary to other measures of risk stratification for patients undergoing HCT. © 2023, The Author(s), under exclusive licence to Springer Nature Limited. |
| Keywords: | retrospective studies; transplantation, homologous; hematopoietic stem cell transplantation; retrospective study; graft versus host reaction; transplantation conditioning; graft vs host disease; allotransplantation; humans; prognosis; human |
| Journal Title: | Bone Marrow Transplantation |
| Volume: | 58 |
| Issue: | 5 |
| ISSN: | 0268-3369 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2023-05-01 |
| Start Page: | 498 |
| End Page: | 505 |
| Language: | English |
| DOI: | 10.1038/s41409-023-01922-8 |
| PUBMED: | 36721042 |
| PROVIDER: | scopus |
| PMCID: | PMC10513445 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding authors are MSK authors: Miriam Sanchez-Escamilla and Miguel-Angel Perales -- Source: Scopus |
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