Advances in the clinical management of high-risk Wilms tumors Review
| Authors: | Ortiz, M. V.; Koenig, C.; Armstrong, A. E.; Brok, J.; de Camargo, B.; Mavinkurve-Groothuis, A. M. C.; Herrera, T. B. V.; Venkatramani, R.; Woods, A. D.; Dome, J. S.; Spreafico, F. |
| Review Title: | Advances in the clinical management of high-risk Wilms tumors |
| Abstract: | Outcomes are excellent for the majority of patients with Wilms tumors (WT). However, there remain WT subgroups for which the survival rate is approximately 50% or lower. Acknowledging that the composition of this high-risk group has changed over time reflecting improvements in therapy, we introduce the authors’ view of the historical and current approach to the classification and treatment of high-risk WT. For this review, we consider high-risk WT to include patients with newly diagnosed metastatic blastemal-type or diffuse anaplastic histology, those who relapse after having been initially treated with three or more different chemotherapeutics, or those who relapse more than once. In certain low- or low middle-income settings, socio-economic factors expand the definition of what constitutes a high-risk WT. As conventional therapies are inadequate to cure the majority of high-risk WT patients, advancement of laboratory and early-phase clinical investigations to identify active agents is urgently needed. © 2023 Wiley Periodicals LLC. |
| Keywords: | cancer chemotherapy; cancer survival; survival rate; histopathology; review; cancer recurrence; cancer patient; cancer staging; outcome assessment; antineoplastic agent; neoplasm staging; recurrence; hematopoietic stem cell transplantation; pathology; kidney neoplasms; high risk patient; risk assessment; kidney tumor; recurrent disease; high risk population; socioeconomics; nephroblastoma; wilms tumor; relapsed; high risk; humans; prognosis; human; middle income country; low income country; cog; siop |
| Journal Title: | Pediatric Blood and Cancer |
| Volume: | 70 |
| Issue: | Suppl. 2 |
| ISSN: | 1545-5009 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2023-05-01 |
| Start Page: | e30342 |
| Language: | English |
| DOI: | 10.1002/pbc.30342 |
| PUBMED: | 37096797 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- This article was published in a special issue of Pediatric Blood & Cancer titled "Supplement: Pediatric Renal Tumors ‐ A HARMONICA Initiative" -- Source: Scopus |
