Hürthle cell carcinoma: A 60-year experience Journal Article


Authors: Stojadinovic, A.; Hoos, A.; Ghossein, R. A.; Urist, M. J.; Leung, D. H. Y.; Spiro, R. H.; Shah, J. P.; Brennan, M. F.; Singh, B.; Shaha, A. R.
Article Title: Hürthle cell carcinoma: A 60-year experience
Abstract: Background: The aim of this study was to define the clinical behavior and prognostic indicators of outcome in Hürthle cell cancer (HCC). Methods: Diagnosis was confirmed for 56 patients with HCC treated between 1940 and 2000, who form the basis of this study. Primary end points were relapse-free survival (RFS) and disease-specific survival (DSS). Data were analyzed with the Kaplan-Meier method and by log-rank test. Results: The extent of thyroid resection did not predict outcome. Recurrence was a significant predictor of tumor-related mortality. Significant adverse predictors of RFS and DSS were degree of invasion, size >4 cm, extrathyroidal extension, and initial nodal or distant metastases. The most significant predictor of outcome was extent of invasion. Eight-year RFS values for low- and high-risk groups were 100% and 24%. Corresponding rates of 8-year DSS were 100% and 58%. Conclusions: Widely invasive HCC is an aggressive malignancy that identifies patients who are at high risk for recurrence and tumor-related death. Patients with HCC have a prognosis that is reliably predicted by degree of invasion, tumor size, extrathyroidal disease extension, and initial nodal or distant metastasis. Recurrence portends a poor outcome. High-risk patients and those with recurrence should be considered for adjuvant therapy.
Keywords: survival; adolescent; adult; cancer survival; child; aged; aged, 80 and over; disease-free survival; middle aged; survival rate; retrospective studies; major clinical study; clinical feature; cancer recurrence; cancer risk; adjuvant therapy; oncocytoma; adenoma, oxyphilic; risk; cancer invasion; thyroidectomy; new york city; thyroid cancer; thyroid neoplasms; kaplan meier method; analysis of variance; disease recurrence; subtotal thyroidectomy; humans; prognosis; human; male; female; article; hurthle cell
Journal Title: Annals of Surgical Oncology
Volume: 9
Issue: 2
ISSN: 1068-9265
Publisher: Springer  
Date Published: 2002-03-01
Start Page: 197
End Page: 203
Language: English
DOI: 10.1245/aso.2002.9.2.197
PUBMED: 11888879
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 14 November 2014 -- Source: Scopus
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MSK Authors
  1. Murray F Brennan
    1053 Brennan
  2. Ronald A Ghossein
    449 Ghossein
  3. Ashok R Shaha
    671 Shaha
  4. Bhuvanesh Singh
    236 Singh
  5. Denis Heng Yan Leung
    114 Leung
  6. Axel Hoos
    28 Hoos
  7. Jatin P Shah
    701 Shah
  8. Ronald H Spiro
    105 Spiro
  9. Marshall   Urist
    9 Urist