Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic Journal Article

   


Authors: Nascimento de Lima, P.; van den Puttelaar, R.; Hahn, A. I.; Harlass, M.; Collier, N.; Ozik, J.; Zauber, A. G.; Lansdorp-Vogelaar, I.; Rutter, C. M.
Article Title: Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic
Abstract: The aftermath of the initial phase of the COVID-19 pandemic may contribute to the widening of disparities in colorectal cancer (CRC) outcomes due to differential disruptions to CRC screening. This comparative microsimulation analysis uses two CISNET CRC models to simulate the impact of ongoing screening disruptions induced by the COVID-19 pandemic on long-term CRC outcomes. We evaluate three channels through which screening was disrupted: delays in screening, regimen switching, and screening discontinuation. The impact of these disruptions on long-term CRC outcomes was measured by the number of life-years lost due to CRC screening disruptions compared to a scenario without any disruptions. While short-term delays in screening of 3-18 months are predicted to result in minor life-years loss, discontinuing screening could result in much more significant reductions in the expected benefits of screening. These results demonstrate that unequal recovery of screening following the pandemic can widen disparities in CRC outcomes and emphasize the importance of ensuring equitable recovery to screening following the pandemic. © 2023, Nascimento de Lima et al.
Keywords: colorectal cancer; cancer screening; colorectal neoplasms; colorectal tumor; epidemiology; early detection of cancer; global health; pandemic; procedures; microsimulation; comparative modeling; humans; human; early cancer diagnosis; pandemics; coronavirus disease 2019; covid-19
Journal Title: eLife
Volume: 12
ISSN: 2050-084X
Publisher: eLife Sciences Publications Ltd.  
Date Published: 2023-05-02
Start Page: e85264
Language: English
DOI: 10.7554/eLife.85264
PUBMED: 37129468
PROVIDER: scopus
PMCID: PMC10154022
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85159543230&doi=10.7554%2feLife.85264&partnerID=40&md5=4074bb8b5bbf0129a13005be646241f6
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Source: Scopus
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MSK Authors
  1. Ann G Zauber
    314 Zauber
  2. Anne Impellizeri Hahn
    17 Hahn
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