Cytologic features of gynecologic germ cell tumors and carcinomas exhibiting germ cell tumor differentiation Journal Article
| Authors: | Hodgson, A.; Kim, V.; Murali, R. |
| Article Title: | Cytologic features of gynecologic germ cell tumors and carcinomas exhibiting germ cell tumor differentiation |
| Abstract: | Background: In this study, the authors sought to describe the cytologic features of primary gynecologic germ cell tumors and carcinomas exhibiting germ cell differentiation because little information currently exists. Methods: An institutional database search was performed to identify histologically confirmed gynecologic germ cell tumors and carcinomas with germ cell tumor differentiation. Available cytologic material was reviewed by three observers, and morphologic features were recorded in addition to patient age at original diagnosis, primary tumor site, site(s) from which the examined cytologic material was obtained, and the type of examined cytologic preparations. Results: In total, 15 cytologic specimens from 12 women (aged 19–82 years) were identified and included touch preparations of core biopsies from various sites (n = 6), fine-needle biopsies (n = 2), pelvic washings (n = 1), ascitic fluids (n = 4), pelvic cyst fluid (n = 1), and endometrial aspirate (n = 1). Of the 12 patients, seven had primary gynecologic germ cell tumors, four had gynecologic (ovarian and endometrial) tumors exhibiting somatic yolk sac tumor-like differentiation, and the remaining patient had an intestinal-type adenocarcinoma arising within an ovarian teratoma. There was morphologic overlap among many of the cases, although cytoplasmic vacuolation/granular cytoplasm was seen in 75% of primary yolk sac tumors or carcinomas with yolk sac tumor differentiation, and dense/squamoid cytoplasm was seen in 100% of teratomatous elements that were sampled. Conclusions: Germ cell tumors and somatic neoplasms exhibiting germ cell tumor differentiation occurring in adult women share some cytologic features and may be difficult to distinguish from one another, although some tumor types showed characteristic cytomorphologic findings. © 2022 American Cancer Society. |
| Keywords: | adult; clinical article; controlled study; human tissue; aged; middle aged; primary tumor; young adult; human cell; clinical feature; histopathology; neoplasm; adenocarcinoma; ovarian neoplasms; cytology; tumor localization; tumor differentiation; cyst fluid; cohort analysis; pathology; data base; medical record review; ovary tumor; carcinoma; cytoplasm; teratoma; neoplasms, germ cell and embryonal; age distribution; ovary teratoma; germ cell tumor; endometrium tumor; yolk sac tumor; cancer morphology; female genital tract tumor; endometrium biopsy; ascites fluid; lavage; cell vacuole; fine needle aspiration biopsy; touch preparation; fine-needle biopsy; gynecologic tract; endodermal sinus tumor; very elderly; humans; human; female; article; granular cytoplasm; cytoplasmic vacuolation; female genital tract carcinoma; pelvic cyst fluid; pelvic washing |
| Journal Title: | Cancer Cytopathology |
| Volume: | 131 |
| Issue: | 4 |
| ISSN: | 1934-662X |
| Publisher: | John Wiley & Sons |
| Date Published: | 2023-04-01 |
| Start Page: | 254 |
| End Page: | 261 |
| Language: | English |
| DOI: | 10.1002/cncy.22673 |
| PUBMED: | 36574209 |
| PROVIDER: | scopus |
| PMCID: | PMC10483219 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Rajmohan Murali -- Export Date: 1 May 2023 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work