Fine-needle aspiration biopsy of nonteratomatous germ cell tumors of the mediastinum Journal Article
| Authors: | Chhieng, D. C.; Lin, O.; Moran, C. A.; Eltoum, I. A.; Jhala, N. C.; Jhala, D. N.; Simsir, A. |
| Article Title: | Fine-needle aspiration biopsy of nonteratomatous germ cell tumors of the mediastinum |
| Abstract: | We assessed the usefulness of fine-needle aspiration biopsy (FNAB) in the diagnosis of mediastinal germ cell tumors (GCTs). In the archives of 3 pathology departments, we found records of 7 patients with mediastinal GCTs who underwent mediastinal FNAB as part of the diagnostic workup. The FNAB smears, results of the immunocytochemical analysis, the corresponding histologic findings, and the clinical charts were reviewed. All patients were men (age range, 24-44 years; mean, 32 years). One patient had a history of testicular mixed GCT 10 years earlier. The 6 primary mediastinal GCTs consisted of 3 seminomas and 3 yolk sac tumors. Based on the cytologic features and immunocytochemical findings, a cytologic diagnosis of GCT was made in 5 cases, including the case of metastatic GCT. In 2 cases, the differential diagnosis was between poorly differentiated carcinoma and GCT. Results of ancillary studies were noncontributory in 1 case, and the aspirate of the second case demonstrated extensive necrosis. Our findings demonstrate that a diagnosis of mediastinal GCT, primary or secondary, can be established with a high degree of accuracy on the basis of FNAB. Immunocytochemical analysis helps confirm the diagnosis. |
| Keywords: | immunohistochemistry; adult; clinical article; human tissue; human cell; diagnostic accuracy; metastasis; diagnosis, differential; differential diagnosis; tumor markers, biological; pathology; tumor marker; chemistry; immunocytochemistry; biopsy, needle; needle biopsy; medical record; carcinoma; testis tumor; testicular neoplasms; teratoma; diagnostic test; aspiration biopsy; mediastinum; germ cell tumor; mediastinum tumor; mediastinal neoplasms; germ cell tumors; seminoma; yolk sac tumor; cytodiagnosis; tumor necrosis; fine-needle aspiration; endodermal sinus tumor; humans; human; male; female; priority journal; article |
| Journal Title: | American Journal of Clinical Pathology |
| Volume: | 118 |
| Issue: | 3 |
| ISSN: | 0002-9173 |
| Publisher: | Oxford University Press |
| Date Published: | 2002-09-01 |
| Start Page: | 418 |
| End Page: | 424 |
| Language: | English |
| DOI: | 10.1309/4dj8-f94d-0puk-npqw |
| PUBMED: | 12219784 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
