Tocilizumab in the treatment of eosinophilic fasciitis: A case study and review of literature Review
| Authors: | El Iskandarani, S.; Khasho, M.; Merashli, M. |
| Review Title: | Tocilizumab in the treatment of eosinophilic fasciitis: A case study and review of literature |
| Abstract: | Eosinophilic fasciitis (EF) is a rare connective-tissue disorder that is characterised by subacute onset of erythema, oedema, and induration of the skin and soft tissues of the limbs and trunk. Although several triggers have been hypothesised to be associated with EF, the aetiology of eosinophilic fasciitis (EF) is still unclear, and several treatment regimens have been proposed to treat this disease. In this article, we report a case of a 72-year-old gentleman with multiple comorbidities who presented to the clinic for diffuse skin thickening present on his forearms, thighs, legs bilaterally, and over the pelvis. The patient was diagnosed with EF and failed multiple treatment regimens including prednisone, methotrexate, rituximab, but finally responded and was maintained on tocilizumab. In this article, we will review the current understanding of EF, diagnostic approach, popular treatments and review other cases of EF in which tocilizumab was used © This work is licensed under a Creative Commons Attribution 4.0 International License |
| Keywords: | clinical article; treatment outcome; treatment response; aged; prednisone; review; case report; cigarette smoking; drug withdrawal; hypertension; methotrexate; rituximab; pelvis; c reactive protein; computer assisted tomography; skin biopsy; differential diagnosis; cyclophosphamide; immunoglobulin; peripheral t cell lymphoma; thigh; laboratory test; vitamin d; comorbidity; etanercept; erythema; azathioprine; folic acid; physical examination; skin induration; blood cell count; leukocyte count; drug dose increase; drug substitution; paraneoplastic syndrome; non insulin dependent diabetes mellitus; cyclosporine; erythrocyte sedimentation rate; chronic obstructive lung disease; leg; forearm; eosinophil count; skin edema; skin thickness; skin fibrosis; risedronic acid; scleroderma; elasticity; mycophenolic acid; body weight loss; tocilizumab; morphea; systemic sclerosis; ebastine; human; male; eosinophilic fasciitis; shulman’s disease; deflazacort; reslizumab; eosinophilia myalgia syndrome; linear scleroderma; toxic oil syndrome |
| Journal Title: | Mediterranean Journal of Rheumatology |
| Volume: | 34 |
| Issue: | 4 |
| ISSN: | 2529-198X |
| Publisher: | Elliniki Reumatologiki Etaireia & Epaggelmatiki Enosi Reumatologon Ellados |
| Date Published: | 2023-03-01 |
| Start Page: | 78 |
| End Page: | 85 |
| Language: | English |
| DOI: | 10.31138/mjr.34.1.78 |
| PROVIDER: | scopus |
| PMCID: | PMC10201092 |
| PUBMED: | 37223590 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 May 2023 -- Source: Scopus |
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