Chronic cutaneous graft-versus-host disease simulating hypertrophic lupus erythematosus-a case report of a new morphologic variant of graft-versus-host Disease Journal Article

  


Authors: Hu, S. W.; Myskowski, P. L.; Papadopoulos, E. B.; Busam, K. J.
Article Title: Chronic cutaneous graft-versus-host disease simulating hypertrophic lupus erythematosus-a case report of a new morphologic variant of graft-versus-host Disease
Abstract: The spectrum of clinical and histopathologic features associated with chronic graft-versus-host disease (GVHD) is broad, with recognized variants simulating scleroderma, lichen sclerosus, eosinophilic fasciitis, and de novo diffuse melanoderma. We report a case of a patient with multiple myeloma who presented approximately 1 year after his allogeneic hematopoietic stem cell transplantation with lesions of chronic lichenoid GVHD that harbored features of hypertrophic lupus erythematosus (LE) and that was initially mistaken for a superficial well-differentiated squamous cell carcinoma (SCC). However, in 4 years of follow-up, the patient failed to develop any evidence of cutaneous or systemic LE, actinic damage, or SCC, and the lesions cleared with topical and systemic treatments appropriate for chronic GVHD. For proper interpretation of the histologic findings of GVHD, it is important for the dermatopathologist to be aware of unusual manifestations. Knowledge of the occurrence of hypertrophic LE and familiarity with its histologic features is also important to avoid an erroneous diagnosis of SCC in immunosuppressed patients. © 2012 by Lippincott Williams & Wilkins.
Keywords: adult; human tissue; clinical feature; case report; squamous cell carcinoma; drug withdrawal; follow up; bortezomib; multiple myeloma; chronic graft versus host disease; drug response; graft versus host reaction; diagnostic error; allogeneic hematopoietic stem cell transplantation; drug substitution; immunosuppressive treatment; tacrolimus; mycophenolic acid 2 morpholinoethyl ester; kidney biopsy; cyclosporin; fluocinonide; chronic graft-versus-host disease; lupus erythematosus; hypertrophic lupus erythematosus; chronic cutaneous graft versus host disease
Journal Title: American Journal of Dermatopathology
Volume: 34
Issue: 6
ISSN: 0193-1091
Publisher: Lippincott Williams & Wilkins  
Date Published: 2012-08-01
Start Page: e81
End Page: e83
Language: English
DOI: 10.1097/DAD.0b013e31823395f0
PROVIDER: scopus
PUBMED: 22307231
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84861589337&partnerID=40&md5=d4bb0aad2baae6dedab61b34e5ae0f84
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 28 January 2013" - "CODEN: AJDOD" - "Source: Scopus"
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Esperanza B Papadopoulos
    417 Papadopoulos
  2. Klaus J Busam
    689 Busam
  3. Patricia Myskowski
    216 Myskowski
Related MSK Work