What is cancer metabolism? Review
| Author: | Finley, L. W. S. |
| Review Title: | What is cancer metabolism? |
| Abstract: | The uptake and metabolism of nutrients support fundamental cellular process from bioenergetics to biomass production and cell fate regulation. While many studies of cell metabolism focus on cancer cells, the principles of metabolism elucidated in cancer cells apply to a wide range of mammalian cells. The goal of this review is to discuss how the field of cancer metabolism provides a framework for revealing principles of cell metabolism and for dissecting the metabolic networks that allow cells to meet their specific demands. Understanding context-specific metabolic preferences and liabilities will unlock new approaches to target cancer cells to improve patient care. © 2023 Elsevier Inc. |
| Keywords: | adult; review; neoplasm; neoplasms; animal; metabolism; animals; cell function; cell fate; patient care; mammal; cancer cell; nutrient; mammals; cell metabolism; bioenergy; energy metabolism; mammal cell; metabolic networks and pathways; cell physiological phenomena; tumor metabolism; biomass production; humans; human |
| Journal Title: | Cell |
| Volume: | 186 |
| Issue: | 8 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2023-04-13 |
| Start Page: | 1670 |
| End Page: | 1688 |
| Language: | English |
| DOI: | 10.1016/j.cell.2023.01.038 |
| PUBMED: | 36858045 |
| PROVIDER: | scopus |
| PMCID: | PMC10106389 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record and PDF. Corresponding author is MSK author Lydia W. S. Finley -- Source: Scopus |
