Plasma renalase levels are associated with the development of acute pancreatitis Journal Article


Authors: Wang, M.; Weiss, F. U.; Guo, X.; Kolodecik, T.; Bewersdorf, J. P.; Laine, L.; Lerch, M. M.; Desir, G.; Gorelick, F. S.
Article Title: Plasma renalase levels are associated with the development of acute pancreatitis
Abstract: Background/objectives: Severe acute pancreatitis is associated with significant morbidity and mortality. Identifying factors that affect the risk of developing severe disease could influence management. Plasma levels of renalase, an anti-inflammatory secretory protein, dramatically decrease in a murine acute pancreatitis model. We assessed this response in hospitalized acute pancreatitis patients to determine if reduced plasma renalase levels occur in humans. Methods: Plasma samples were prospectively and sequentially collected from patients hospitalized for acute pancreatitis. Two forms of plasma renalase, native (no acid) and acidified, were measured by ELISA and RNLS levels were compared between healthy controls and patients with mild and severe disease (defined as APACHE-II score ≥7) using nonparametric statistical analysis. Results: Control (33) and acute pancreatitis (mild, 230 (76.7%) and severe, 70 (23.3%) patients were studied. Acidified RNLS levels were lower in pancreatitis patients: Control: 10.1 μg/ml, Mild 5.1 μg/ml, Severe 6.0 μg/ml; p < 0.001. Native RNLS levels were increased in AP: Control: 0.4 μg/ml, Mild 0.9 μg g/ml, Severe 1.2 μg/ml p < 0.001; those with severe AP trended to have higher native RNLS levels than those with mild disease (p = 0.056). In patients with severe AP, higher APACHE-II scores at 24 h after admission correlated with lower acid-sensitive RNLS levels on admission (r = −0.31, p = 0.023). Conclusion: Low plasma acidified RNLS levels, and increased native RNLS levels are associated with AP. Additional studies should assess the clinical correlation between plasma RNLS levels and AP severity and outcomes. © 2023 IAP and EPC
Keywords: controlled study; major clinical study; clinical feature; histopathology; prospective study; mouse; animal; animals; mice; clinical assessment; cohort analysis; enzyme linked immunosorbent assay; hospitalization; disease severity; severity of illness index; pilot study; pancreatitis; hospital admission; acute disease; sample; amine oxidase (flavin containing); acidity; severity; enzyme blood level; complication; apache; acute pancreatitis; humans; prognosis; human; article; monoamine oxidase; renalase
Journal Title: Pancreatology
Volume: 23
Issue: 2
ISSN: 1424-3903
Publisher: Karger  
Date Published: 2023-03-01
Start Page: 158
End Page: 162
Language: English
DOI: 10.1016/j.pan.2023.01.001
PUBMED: 36697349
PROVIDER: scopus
PMCID: PMC11847554
DOI/URL:
Notes: Article -- Source: Scopus
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