More than just skin-deep: A review of imaging’s role in guiding CAR T-cell therapy for advanced melanoma Review
| Authors: | Prendergast, C. M.; Capaccione, K. M.; Lopci, E.; Das, J. P.; Shoushtari, A. N.; Yeh, R.; Amin, D.; Dercle, L.; De Jong, D. |
| Review Title: | More than just skin-deep: A review of imaging’s role in guiding CAR T-cell therapy for advanced melanoma |
| Abstract: | Advanced melanoma is one of the deadliest cancers, owing to its invasiveness and its propensity to develop resistance to therapy. Surgery remains the first-line treatment for early-stage tumors but is often not an option for advanced-stage melanoma. Chemotherapy carries a poor prognosis, and despite advances in targeted therapy, the cancer can develop resistance. CAR T-cell therapy has demonstrated great success against hematological cancers, and clinical trials are deploying it against advanced melanoma. Though melanoma remains a challenging disease to treat, radiology will play an increasing role in monitoring both the CAR T-cells and response to therapy. We review the current imaging techniques for advanced melanoma, as well as novel PET tracers and radiomics, in order to guide CAR T-cell therapy and manage potential adverse events. © 2023 by the authors. |
| Keywords: | melanoma; radiology; metastases; radiomics; car t-cell; car t-cell imaging; car t-cell toxicity; pet radiotracers |
| Journal Title: | Diagnostics |
| Volume: | 13 |
| Issue: | 5 |
| ISSN: | 2075-4418 |
| Publisher: | MDPI |
| Date Published: | 2023-03-01 |
| Start Page: | 992 |
| Language: | English |
| DOI: | 10.3390/diagnostics13050992 |
| PROVIDER: | scopus |
| PMCID: | PMC10000712 |
| PUBMED: | 36900136 |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
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41Das -
7De Jong
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