Адоптивная иммунотерапия генетически модифицированными Т-лимфоцитами, экспрессирующими химерные антигенные рецепторы Journal Article

  


Authors: Pavlova, A.; Maschan, M.; Ponomarev, V. B.
Article Title: Адоптивная иммунотерапия генетически модифицированными Т-лимфоцитами, экспрессирующими химерные антигенные рецепторы
Abstract: Significant mortality due to oncological diseases as a whole, and oncohematological diseases in particular, motivates scientific and medical community to develop new treatment methods. One of the newest methods is adoptive cell therapy using patient's own T-cells modified to express chimeric antigen receptors (CAR) to tumor-specific antigens. Despite high cost and side effects of treatment, promising clinical trials even in patients with advanced disease allow to anticipate successful use of this method in clinical practice. The article includes a review of the main principles of this technique, published results of clinical studies of CAR T-cells with a focus on CD19 gene targeting, complications of this therapy, mechanisms of tumor resistance to CAR T-cells, and potential ways to overcome it.
Keywords: chimeric antigen receptor; modified t-cells; adoptive therapy; oncohematological diseases
Journal Title: Oncogematologiya
Volume: 12
Issue: 1
ISSN: 1818-8346
Publisher: ABV Press, LLC  
Date Published: 2017-01-01
Start Page: 17
End Page: 32
Language: Russian
DOI: 10.17650/1818-8346-2017-12-1-17-32
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85034774168&doi=10.17650%2f1818-8346-2017-12-1-17-32&partnerID=40&md5=ddd1ed91060b62aeb139c2b2af63d7d0
Notes: Article: "Adoptitive immunotherapy with genetically engineered T lymphocytes modified to express chimeric antigen receptors" -- Export Date: 2 January 2018 -- Source: Scopus
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MSK Authors
  1. Vladimir Ponomarev
    123 Ponomarev
  2. Anna Pavlova
    1 Pavlova
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