Cellular and genetic programs underlying cerebellum development Journal Article
| Authors: | K. Lawton, A.; Willett, R.; Joyner, A. L. |
| Article Title: | Cellular and genetic programs underlying cerebellum development |
| Abstract: | The cerebellum is a late developing structure compared to the rest of the central nervous system (CNS), and houses more cells than the entire rest of the brain in a complex set of folds. To accommodate production of the large number of cells, the cerebellum has two progenitor zones: a ventricular progenitor zone producing astrocytes and all inhibitory neurons, and a unique progenitor zone, the rhombic lip, dedicated to excitatory neuron production. In this chapter, we discuss how the inhibitory Purkinje cells, which integrate the incoming information and moderate the output neurons of the cerebellar nuclei, play a key role during development in ensuring appropriate production of the other neurons/astrocytes of the cerebellar cortex. We describe key transcription factors that regulate development of the two progenitor populations and the lineage relationships of the neurons and astrocytes produced by each. We conclude with a discussion of cerebellar foliation that compartmentalizes these cell types into the final three-dimensional working structure. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG. |
| Keywords: | purkinje cells; interneurons; neural stem cells; astrocytes; cerebellar nuclei; granule cells; rhombic lip; foliation; ventricular zone; bergmann glia |
| Journal Title: | Contemporary Clinical Neuroscience |
| ISSN: | 2627-535X |
| Publisher: | Humana Press Inc |
| Date Published: | 2023-01-01 |
| Start Page: | 45 |
| End Page: | 67 |
| Language: | English |
| DOI: | 10.1007/978-3-031-23104-9_3 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter in "Development of the Cerebellum from Molecular Aspects to Diseases" 2nd ed. (ISBN: 978-3-031-23103-2) -- Source: Scopus |
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