Cellular and genetic programs underlying cerebellum development Journal Article
| Authors: | Joyner, A. L.; Willett, R.; Lawton, A. |
| Article Title: | Cellular and genetic programs underlying cerebellum development |
| Abstract: | The cerebellum is a late developing structure compared to the rest of the central nervous system (CNS) and houses more cells than the entire rest of the brain in a complex set of folds. To accommodate production of the large number of cells, the cerebellum has not only a ventricular progenitor zone that produces all the glia and inhibitory neurons but also a unique progenitor zone, the rhombic lip, dedicated to excitatory neuron production. In this chapter we discuss how the inhibitory Purkinje cells, which integrate the incoming information and moderate the output neurons of the cerebellar nuclei, play a key role during development in ensuring appropriate production of the other neurons/astrocytes of the cerebellar cortex. Key transcription factors that regulate development of the two progenitor populations and the lineage relationships of the neurons and astrocytes produced by each are described, followed by a discussion of cerebellar foliation. © 2017, Springer International Publishing AG. |
| Keywords: | purkinje cells; interneurons; neural stem cells; astrocytes; cerebellar nuclei; granule cells; rhombic lip; foliation; ventricular zone; bergmann glia |
| Journal Title: | Contemporary Clinical Neuroscience |
| Volume: | 21 |
| ISSN: | 2627-535X |
| Publisher: | Humana Press Inc |
| Date Published: | 2017-01-01 |
| Start Page: | 45 |
| End Page: | 65 |
| Language: | English |
| DOI: | 10.1007/978-3-319-59749-2_3 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Chapter in "Development of the Cerebellum from Molecular Aspects to Diseases" (ISBN: 978-3-319-59748-5) -- Export Date: 2 November 2021 -- Source: Scopus |
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