Cutaneous adverse events of systemic melanoma treatments Book Section
| Authors: | Menzer, C.; Chen, S. T.; Phillips, G. S.; Lacouture, M. E. |
| Editors: | Fisher, D. E.; Bastian, B. C. |
| Article/Chapter Title: | Cutaneous adverse events of systemic melanoma treatments |
| Abstract: | Cutaneous adverse events (AEs) are frequent with systemic melanoma treatments. As a result of a paradigmatic shift in melanoma management from traditional cytotoxic chemotherapy to immunotherapies and targeted therapies as first-line treatment, the spectrum of skin AEs to these treatments has significantly broadened. Cutaneous toxicities from anticancer therapy manifest as doubly burdensome as visible stigmatization often carries profound psychosocial implications. Early detection and treatment help to minimize a reduction in patients’ quality of life and maximize anticancer treatment adherence and outcome. The knowledge of typical presentations associated with the specific drug regimen administered to the patient is essential for timely management of these conditions. A dermatological evaluation of the skin condition appears to be essential for an interdisciplinary approach as very often even dramatic skin presentations do not necessitate a cessation of the potentially lifesaving antineoplastic drug. Since the onset of AEs of some therapies can take up to several months or years and may also occur in cancer survivors long after completion of their therapy, thorough dermatological follow-up may be advised even after successful completion of antineoplastic treatments. © Springer Science+Business Media, LLC, part of Springer Nature 2019. |
| Keywords: | chemotherapy; cutaneous toxicities; immune checkpoint inhibitor (ici); adverse events (aes); braf inhibitor (brafi); mek inhibitor (meki) |
| Book Title: | Melanoma |
| ISBN: | 978-1-4614-7148-6 |
| Publisher: | Springer |
| Publication Place: | New York, NY |
| Date Published: | 2019-01-01 |
| Start Page: | 743 |
| End Page: | 771 |
| Language: | English |
| DOI: | 10.1007/978-1-4614-7147-9_38 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book chapter: 36 -- This chapter can be found under "Part III Clinical Management" -- Source: Scopus |
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