4D lung MRI with high-isotropic-resolution using half-spoke (UTE) and full-spoke 3D radial acquisition and temporal compressed sensing reconstruction Journal Article
| Authors: | Wu, C.; Krishnamoorthy, G.; Yu, V.; Subashi, E.; Rimner, A.; Otazo, R. |
| Article Title: | 4D lung MRI with high-isotropic-resolution using half-spoke (UTE) and full-spoke 3D radial acquisition and temporal compressed sensing reconstruction |
| Abstract: | Objective. To develop a respiratory motion-resolved four-dimensional (4D) magnetic resonance imaging (MRI) technique with high-isotropic-resolution (1.1 mm) using 3D radial sampling, camera-based respiratory motion sensing, and temporal compressed sensing reconstruction for lung cancer imaging. Approach. Free-breathing half- and full-spoke 3D golden-angle radial acquisitions were performed on eight healthy volunteers and eight patients with lung tumors of varying size. A back-and-forth k-space ordering between consecutive interleaves of the 3D radial acquisition was performed to minimize eddy current-related artifacts. Data were sorted into respiratory motion states using camera-based motion navigation and 4D images were reconstructed using temporal compressed sensing to reduce scan time. Normalized sharpness indices of the diaphragm, apparent signal-to-noise ratio (aSNR) and contrast-to-noise ratio (CNR) of the lung tumor (patients only), liver, and aortic arch were compared between half- and full-spoke 4D MRI images to evaluate the impact of respiratory motion and image contrast on 4D MRI image quality. Respiration-induced changes in lung volumes and center of mass shifts were compared between half- and full-spoke 4D MRI measurements. In addition, the motion measurements from 4D MRI and the same-day 4D CT were presented in one of the lung tumor patients. Main results. Half-spoke 4D MRI provides better visualization of the lung parenchyma, while full-spoke 4D MRI presents sharper diaphragm images and higher aSNR and CNR in the lung tumor, liver, and aortic arch. Lung volume changes and center of mass shifts measured by half- and full-spoke 4D MRI were not statistically different. For the patient with 4D MRI and same-day 4D CT, lung volume changes and center of mass shifts were generally comparable. Significance. This work demonstrates the feasibility of a motion-resolved 4D MRI technique with high-isotropic-resolution using 3D radial acquisition, camera-based respiratory motion sensing, and temporal compressed sensing reconstruction for treatment planning and motion monitoring in radiotherapy of lung cancer. © 2023 The Author(s). Published on behalf of Institute of Physics and Engineering in Medicine by IOP Publishing Ltd. |
| Keywords: | nuclear magnetic resonance imaging; magnetic resonance imaging; lung neoplasms; radiotherapy; diagnostic imaging; lung tumor; computerized tomography; medical imaging; tumors; imaging, three-dimensional; lung; artifact; respiration; biological organs; artifacts; diseases; blood vessels; image reconstruction; respiratory motions; lung volume; breathing; signal to noise ratio; procedures; respiratory motion; cameras; compressed sensing; three-dimensional imaging; four dimensional computed tomography; four-dimensional computed tomography; humans; human; diaphragms; radial; isotropic resolution; compressed-sensing; 4d mri; arches; 4d magnetic resonance imaging; camera-based; centers-of-mass |
| Journal Title: | Physics in Medicine and Biology |
| Volume: | 68 |
| Issue: | 3 |
| ISSN: | 0031-9155 |
| Publisher: | IOP Publishing Ltd |
| Date Published: | 2023-02-07 |
| Start Page: | 035017 |
| Language: | English |
| DOI: | 10.1088/1361-6560/acace6 |
| PUBMED: | 36535035 |
| PROVIDER: | scopus |
| PMCID: | PMC10257135 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record and PDF. Corresponding author is MSK author Can Wu -- Export Date: 1 March 2023 -- Source: Scopus |
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21Yu -
19Wu
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