Rapid dynamic contrast-enhanced MRI for small animals at 7T using 3D ultra-short echo time and golden-angle radial sparse parallel MRI Journal Article


Authors: Zhang, J.; Feng, L.; Otazo, R.; Kim, S. G.
Article Title: Rapid dynamic contrast-enhanced MRI for small animals at 7T using 3D ultra-short echo time and golden-angle radial sparse parallel MRI
Abstract: Purpose: To develop a rapid dynamic contrast-enhanced MRI method with high spatial and temporal resolution for small-animal imaging at 7 Tesla. Methods: An ultra-short echo time (UTE) pulse sequence using a 3D golden-angle radial sampling was implemented to achieve isotropic spatial resolution with flexible temporal resolution. Continuously acquired radial spokes were grouped into subsets for image reconstruction using a multicoil compressed sensing approach (Golden-angle RAdial Sparse Parallel; GRASP). The proposed 3D-UTE-GRASP method with high temporal and spatial resolutions was tested using 7 mice with GL261 intracranial glioma models. Results: Iterative reconstruction with different temporal resolutions and regularization factors λ showed that, in all cases, the cost function decreased to less than 2.5% of its starting value within 20 iterations. The difference between the time-intensity curves of 3D-UTE-GRASP and nonuniform fast Fourier transform (NUFFT) images was minimal when λ was 1% of the maximum signal intensity of the initial NUFFT images. The 3D isotropic images were used to generate pharmacokinetic parameter maps to show the detailed images of the tumor characteristics in 3D and also to show longitudinal changes during tumor growth. Conclusion: This feasibility study demonstrated that the proposed 3D-UTE-GRASP method can be used for effective measurement of the 3D spatial heterogeneity of tumor pharmacokinetic parameters. © 2018 International Society for Magnetic Resonance in Medicine
Keywords: dce-mri; parallel imaging; compressed sensing; 3d golden angle radial sampling; grasp; ute
Journal Title: Magnetic Resonance in Medicine
Volume: 81
Issue: 1
ISSN: 0740-3194
Publisher: John Wiley & Sons  
Date Published: 2019-01-01
Start Page: 140
End Page: 152
Language: English
DOI: 10.1002/mrm.27357
PROVIDER: scopus
PMCID: PMC6258350
PUBMED: 30058079
DOI/URL:
Notes: Magn. Reson. Med. -- Export Date: 2 January 2019 -- Article -- CODEN: MRMEE C2 - 30058079 -- Source: Scopus
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
  1. Li Feng
    10 Feng