Preoperative localization of breast lesions: Comparing digital breast tomosynthesis-guided radioactive seed localization versus standard 2D stereotactic radioactive seed localization Journal Article

   

Authors:	Hogan, M. P.; Lynch, D.; Sevilimedu, V.; Martinez, D. F.; Saphier, N. B.
Article Title:	Preoperative localization of breast lesions: Comparing digital breast tomosynthesis-guided radioactive seed localization versus standard 2D stereotactic radioactive seed localization
Abstract:	Purpose: To compare single seed digital breast tomosynthesis-guided radioseed localization (DBT-L) to standard 2D stereotactic-guided radioseed localization (SGL) of the breast. Methods: A retrospective review of a large tertiary cancer center's database yielded 68 women who underwent preoperative DBT-L from March 2019–December 2019 and a matched cohort of 65 women who underwent SGL during the same period. The electronic medical record and radiology were reviewed for patient characteristics including breast density, exam technique, pre- and post-operative pathology, exam duration, and radiation dose to the patient. To compare margin outcomes between the groups, the chi-square test of independence was used; to compare continuous outcomes such as exam duration and total dose, the Wilcoxon rank sum test was used. Results: DBT-L and SGL localization targets included biopsy marker (62/68, 91% vs 55/65, 85%), distortion (4/68, 6% vs 2/65, <3%), focal asymmetry (1/68 and 1/65, < 2% for both), calcifications (1/68, <2% vs 4/65, 6%), and anatomic landmarks (0% vs 3/65, 5%). 72% and 71% of localizations were performed for malignant pathology in the DBT-L and SGL groups, respectively. The median duration of DBT-L was 8.3 min vs 10.3 min for SGL, representing statistically significant time savings (p = 0.003). The median total organ dose of DBT-L was 8.6 mGy vs 10.4 mGy for SGL, representing statistically significant dose savings (p = 0.018). The incidence of positive margins at surgery was not statistically different between the groups (p = 0.26). Conclusion: DBT-L demonstrates both time and dose savings for the patient compared to SGL without compromising surgical outcome. © 2023 Elsevier Inc.
Keywords:	adult; human tissue; treatment outcome; aged; major clinical study; comparative study; radiation dose; preoperative evaluation; breast cancer; incidence; cohort analysis; pathology; retrospective study; postoperative complication; electronic medical record; radiology; tomography; radioactivity; surgery; medical computing; breast surgery; diseases; breast biopsy; breast lesion; clinical examination; surgical margin; statistical tests; breast calcification; breast density; tomosynthesis; preoperative localization; radioactive seed localization; seed localization; radioactive seed; human; female; article; anatomic landmark; tertiary care center; two-dimensional imaging; biomineralization; digital breast tomosynthesis; localisation; presurgical localization
Journal Title:	Clinical Imaging
Volume:	96
ISSN:	0899-7071
Publisher:	Elsevier Inc.
Date Published:	2023-04-01
Start Page:	34
End Page:	37
Language:	English
DOI:	10.1016/j.clinimag.2022.12.012
PUBMED:	36773530
PROVIDER:	scopus
PMCID:	PMC10646817
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85147605110&doi=10.1016%2fj.clinimag.2022.12.012&partnerID=40&md5=4c52b4af35e992dbde68800269a3ba96
Notes:	Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding author is Molly Hogan -- Export Date: 1 March 2023 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/203241