Safety and efficacy of radioactive seed localization with I-125 prior to lumpectomy and/or excisional biopsy Journal Article
| Authors: | Sung, J. S.; King, V.; Thornton, C. M.; Brooks, J. D.; Fry, C. W.; El-Tamer, M.; Dauer, L. T.; Brogi, E.; St Germain, J. M.; Morris, E. A. |
| Article Title: | Safety and efficacy of radioactive seed localization with I-125 prior to lumpectomy and/or excisional biopsy |
| Abstract: | Purpose To evaluate the safety and efficacy of pre-operative I-125 radioactive seed localization (RSL) as an alternative to wire localization (WL). Methods A waiver was granted by the institutional review board for this HIPAA compliant study. Review of 356 consecutive single site nonpalpable mammographic and ultrasound guided I-125 RSLs done between November 2011 and April 2012 was conducted. Preoperative mammograms and specimen radiographs were reviewed for seed-target distance, lesion location, and target/seed removal. During a brief surgical training period, 35 of 356 women had both RSL and wire localization (WL) of the same lesion. Chi-square and single sample t-tests were used to compare margin status and duration of procedures. Results Of the 356 RSLs, 303 (85.1%) were performed ≥1 day before surgery. Mammographic guidance was used in 330 (93%) and ultrasound in 26 (7%). Mean seed to target distance was 1 mm (range 0-20 mm); all targeted lesions were retrieved. In 31 women in whom mammographic guidance was used for both RSL and WL, median procedure time was not significantly different (RSL 9.0 min; WL 7.0 min; p = 0.91), and median seed migration distance was <1 mm (range 0-15 mm). No difference was detected between margin status with RSL alone versus WL (p = 0.40 and p = 0.65 for positive and <1 mm margins, respectively). Two adverse events occurred requiring an additional wire/surgery. Conclusion RSL ≥ 1 day before surgery is a safe effective procedure for pre-operative localization, with few adverse events and surgical outcomes comparable to those achieved with wire localization. © 2013 Elsevier Ireland Ltd. |
| Keywords: | mammography; breast intervention |
| Journal Title: | European Journal of Radiology |
| Volume: | 82 |
| Issue: | 9 |
| ISSN: | 0720-048X |
| Publisher: | Elsevier B.V |
| Date Published: | 2013-09-01 |
| Start Page: | 1453 |
| End Page: | 1457 |
| Language: | English |
| DOI: | 10.1016/j.ejrad.2013.04.008 |
| PROVIDER: | scopus |
| PUBMED: | 23684386 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 September 2013" - "CODEN: EJRAD" - "Source: Scopus" |
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