Biochemical measures of ovarian function in female survivors of retinoblastoma treated with intra-arterial melphalan: An initial report Journal Article
| Authors: | Marathe, P. H.; Dunkel, I. J.; Francis, J. H.; Antal, Z.; Gobin, Y. P.; Abramson, D. H.; Friedman, D. N. |
| Article Title: | Biochemical measures of ovarian function in female survivors of retinoblastoma treated with intra-arterial melphalan: An initial report |
| Abstract: | Since 2006, ophthalmic artery chemosurgery (OAC) has been used for ocular-sparing treatment of retinoblastoma. Systemic exposure to melphalan is known to cause ovarian dysfunction, but the effect of melphalan-based OAC has not yet been determined. Here, we assess biochemical and symptomatic measures of ovarian function in a cohort of pubertal female survivors of retinoblastoma treated with melphalan-based OAC. These 13 patients all had normal gonadotropins at a median age of 11.1 years, 9.6 years from the completion of therapy. None had symptoms of ovarian dysfunction. This study provides initial evidence that ovarian function remains intact after melphalan-based OAC. © 2022 Taylor & Francis Group, LLC. |
| Keywords: | child; treatment outcome; retrospective studies; topotecan; carboplatin; melphalan; retinoblastoma; retina tumor; retinal neoplasms; retrospective study; survivor; survivors; infant; survivorship; intraarterial drug administration; infusions, intra-arterial; electroretinography; ophthalmic artery; humans; human; female; ovarian function |
| Journal Title: | Ophthalmic Genetics |
| Volume: | 43 |
| Issue: | 6 |
| ISSN: | 1381-6810 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2022-01-01 |
| Start Page: | 806 |
| End Page: | 808 |
| Language: | English |
| DOI: | 10.1080/13816810.2022.2132516 |
| PUBMED: | 36695494 |
| PROVIDER: | scopus |
| PMCID: | PMC10364467 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2023 -- Source: Scopus |
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