Pilot study of ONCOS-102 and pembrolizumab: Remodeling of the tumor microenvironment and clinical outcomes in anti-PD-1-resistant advanced melanoma Journal Article

   

Authors:	Shoushtari, A. N.; Olszanski, A. J.; Nyakas, M.; Hornyak, T. J.; Wolchok, J. D.; Levitsky, V.; Kuryk, L.; Hansen, T. B.; Jäderberg, M.
Article Title:	Pilot study of ONCOS-102 and pembrolizumab: Remodeling of the tumor microenvironment and clinical outcomes in anti-PD-1-resistant advanced melanoma
Abstract:	Purpose: Intratumoral oncolytic virotherapy may overcome anti-PD(L)-1 resistance by triggering pro-inflammatory remo-deling of the tumor microenvironment. This pilot study inves-tigated ONCOS-102 (oncolytic adenovirus expressing GM-CSF) plus anti-programmed cell death protein 1 (PD)-1 therapy in anti-PD-1-resistant melanoma. Patients and Methods: Patients with advanced melanoma progressing after prior PD-1 blockade received intratumoral ONCOS-102 either as priming with 3 doses (3 x 1011 viral particles) during Week 1 [Part 1 (sequential treatment)] or as 4-dose priming and 8 booster doses every 3 weeks [Part 2 (combination treatment)]. From Week 3, all patients received pembrolizumab every 3 weeks (<= 8 doses). The primary endpoint was safety. Objective response rate (ORR), progression-free survival, and immunologic activation in repeat biopsies were also investigated. Results: In 21 patients (Part 1, n = 9; Part 2, n = 12) ONCOS-102 plus pembrolizumab was well tolerated: most adverse events (AE) were mild/moderate in severity. Pyrexia (43%), chills (43%), and nausea (28%) were the most common ONCOS-102-related AEs. There were no dose-limiting toxicities. ORR was 35% [response evaluation in solid tumors (RECIST) 1.1, irRECIST]. Reduction in size of >= 1 non-injected lesions observed in 53% patients indicated a systemic effect. In injected tumors, persistent immune-related gene expression and T-cell infiltration were associated with clinical benefit. Viral persistence and efficacy in injected and non -injected lesions without additional toxicity supported Part 2 dosing regimen in future studies. Conclusions: ONCOS-102 plus pembrolizumab was well toler-ated and led to objective responses in patients with anti-PD-1- resistant advanced melanoma. ONCOS-102 promoted T-cell infil-tration, particularly cytotoxic CD8+ T cells, which persisted at Week 9, driving clinical benefit. Further investigation of ONCOS-102 plus PD-1 blockade is warranted.
Keywords:	ipilimumab; resistance; pd-1 blockade; anti-pd-1 therapy; relatlimab
Journal Title:	Clinical Cancer Research
Volume:	29
Issue:	1
ISSN:	1078-0432
Publisher:	American Association for Cancer Research
Date Published:	2023-01-01
Start Page:	100
End Page:	109
Language:	English
ACCESSION:	WOS:000907927800001
DOI:	10.1158/1078-0432.Ccr-22-2046
PROVIDER:	wos
PMCID:	PMC9811163
PUBMED:	36112545
Notes:	The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Alexander N. Shoushtari -- Source: Wos

https://synapse.mskcc.org/synapse/works/has_related_data_chk/202827