Analyzing adherence to the 2016 Infectious Diseases Society of America guidelines for candidemia in cancer patients Journal Article

   


Authors: Lehmann, D. M.; Cohen, N.; Lin, I. H.; Alexander, S.; Kathuria, R.; Kerpelev, M.; Taur, Y.; Seo, S. K.
Article Title: Analyzing adherence to the 2016 Infectious Diseases Society of America guidelines for candidemia in cancer patients
Abstract: Background Candidemia is associated with morbidity and mortality in cancer patients. We analyzed adherence to the 2016 Infectious Diseases Society of America (IDSA) candidiasis guidelines and the reasons for guideline nonadherence. We also investigated whether matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) improved time to effective antifungal therapy compared with historical data (median, 43.2 hours). Methods Cancer patients with candidemia between 1/1/17 and 12/31/19 were included. Adherence to 7 individual IDSA guideline components was assessed. Composite IDSA guideline adherence (defined as meeting >= 6 guideline components) was also assessed. Charts were reviewed to examine reasons for noncompliance. Results Of 157 patients with candidemia, 150 (95.5%) had infectious disease (ID) consultation. The median total time from blood culture collection to antifungal initiation was 42.1 hours. Excluding 39 patients with short treatment due to death, there was 100% adherence with surveillance blood cultures, followed by antifungal susceptibility testing (117/118, 99.2%), initial appropriate therapy (117/118, 99.2%), antifungal duration (110/118, 93.2%), line removal (82/91, 90.1%), eye exams (93/118, 78.8%), and step-down therapy (69/94, 73.4%). A quarter (30/118) did not meet composite IDSA guideline adherence. Univariate logistic regression suggested a relationship between poor cancer prognosis and incomplete adherence to the 2016 IDSA candidiasis guidelines (odds ratio, 8.6; 95% CI, 1.6-47). Conclusions The addition of MALDI-TOF did not shorten time to effective antifungal therapy. Nearly all patients were seen by ID for candidemia. Poor cancer prognosis was a common factor for incomplete composite adherence to the 2016 IDSA candidiasis guidelines.
Keywords: blood; guideline adherence; surveillance; candidemia; cancer patients; clinical-practice guidelines; cancer prognosis; amphotericin-b
Journal Title: Open Forum Infectious Diseases
Volume: 9
Issue: 12
ISSN: 2328-8957
Publisher: Oxford University Press  
Date Published: 2022-12-01
Start Page: ofac555
Language: English
ACCESSION: WOS:000900002000004
DOI: 10.1093/ofid/ofac555
PROVIDER: wos
PMCID: PMC9757685
PUBMED: 36540383
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF. Corresponding author is MSK author Susan K. Seo. -- Source: Wos
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MSK Authors
  1. Susan Seo
    120 Seo
  2. Ying Taur
    147 Taur
  3. Nina Cohen Orsini
    32 Cohen Orsini
  4. Marina Kerpelev
    10 Kerpelev
  5. I-Hsin Lin
    16 Lin
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