F-18 meta-fluorobenzylguanidine PET imaging of myocardial sympathetic innervation Journal Article

   


Authors: Grkovski, M.; Zanzonico, P. B.; Modak, S.; Humm, J. L.; Narula, J.; Pandit-Taskar, N.
Article Title: F-18 meta-fluorobenzylguanidine PET imaging of myocardial sympathetic innervation
Abstract: Background: I-123 meta-iodobenzylguanidine (MIBG) imaging has long been employed to noninvasively assess the integrity of human norepinephrine transporter-1 and, hence, myocardial sympathetic innervation. Positron-emitting F-18 meta-fluorobenzylguanidine (MFBG) has recently been developed for potentially superior quantitative characterization. We assessed the feasibility of MFBG imaging of myocardial sympathetic innervation. Methods: 16 patients were imaged with MFBG PET (30-minute dynamic imaging of chest, followed by 3 whole-body acquisitions between 30 minutes and 4-hour post-injection). Blood kinetics were assessed from multiple samples. Pharmacokinetic modeling with reversible 1- and 2-compartment models was performed. Kinetic rate constants were re-calculated from truncated datasets. All patients underwent concurrent MIBG SPECT. Results: MFBG myocardial uptake was rapid and sustained; the mean standardized uptake value (SUV (mean ± standard deviation)) was 5.1 ± 2.2 and 3.4 ± 1.9 at 1 hour and 3-4-hour post-injection, respectively. The mean K1 and distribution volume (VT) were 1.1 ± 0.6 mL/min/g and 34 ± 22 mL/cm3, respectively. Both were reproducible when re-calculated from truncated 1-hour datasets (Intraclass Correlation Coefficient of 0.99 and 0.91, respectively). Spearman’s ρ = 0.86 between MFBG SUV and VT and 0.80 between MFBG PET-derived VT and MIBG SPECT-derived heart-to-mediastinum activity concentration ratio. Conclusion: MFBG is a promising PET radiotracer for the assessment of myocardial sympathetic innervation. © 2022, The Author(s) under exclusive licence to American Society of Nuclear Cardiology.
Keywords: adolescent; adult; child; clinical article; aged; unclassified drug; doxorubicin; positron emission tomography; radiopharmaceuticals; reproducibility; diagnostic imaging; neuroblastoma; quantitative analysis; heart failure; positron-emission tomography; radiopharmaceutical agent; (3 iodobenzyl)guanidine; 3-iodobenzylguanidine; tracer; fluorine 18; innervation; dipeptidyl carboxypeptidase inhibitor; heart; pharmacokinetic modeling; myocardium; mibg; tomography, emission-computed, single-photon; dynamic pet; single photon emission computed tomography; sympathetic innervation; amlodipine; sympathetic nervous system; procedures; adrenergic system; doxazosin; humans; human; male; female; article; meta fluorobenzylguanidine f 18; volume of distribution; cardiac muscle; mean standardized uptake value; mfbg; myocardial imaging
Journal Title: Journal of Nuclear Cardiology
Volume: 29
Issue: 6
ISSN: 1071-3581
Publisher: Springer  
Date Published: 2022-12-01
Start Page: 3179
End Page: 3188
Language: English
DOI: 10.1007/s12350-021-02813-5
PUBMED: 34993893
PROVIDER: scopus
PMCID: PMC10155237
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122343330&doi=10.1007%2fs12350-021-02813-5&partnerID=40&md5=c1bc4b25552f04e4632b34082f920d86
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record and PDF. Corresponding author is MSK author Neeta Pandit-Taska -- Export Date: 1 February 2023 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Shakeel Modak
    249 Modak
  2. Neeta Pandit-Taskar
    342 Pandit-Taskar
  3. John Laurence Humm
    433 Humm
  4. Pat B Zanzonico
    355 Zanzonico
  5. Milan Grkovski
    64 Grkovski
Related MSK Work